Cao Jinjin, Zhang Weiying, Hu Jiajie, Huang Yan, Zhao Li, Cai Rong, Bao Ying, Li Mei
Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Department of Emergency, Children's Hospital of Nanjing Medical University, Nanjing, China.
Ann Palliat Med. 2020 Sep;9(5):3028-3037. doi: 10.21037/apm-20-582. Epub 2020 Sep 2.
Polyethylene glycol (PEG) has been widely used for bowel preparation. However, the efficacy and safety of single and split dose PEG for bowel preparation in children undergoing colonoscopy remain unclear, it is necessary to evaluate the role of single and split dose PEG for bowel preparation in children population.
PubMed et al. databases up to September 1, 2019 were systematically searched. Randomized controlled trials (RCTs) single and split dose PEG for bowel preparation in children undergoing colonoscopy were included. Based on the heterogeneity, data were synthesized using random-effects or fixed-effects models. Results were expressed as Mantel-Haenszel style odds ratio (OR) or mean difference (MD) with 95% confidence interval (95% CI).
Four RCTs with 249 children were included. There was no significantly difference in the efficacy of single and split dose PEG for bowel preparation (OR =0.36, 95% CI: -0.12 to 1.10). The acceptability of split dose PEG for bowel preparation was significantly higher than that of single dose (OR =0.50, 95% CI: 0.29 to 0.85); the incidence of nausea in split dose PEG for bowel preparation was significantly lower than that of single dose (OR =2.1, 95% CI: 1.29 to 3.42); there was no significant difference on the incidence of abdominal pain between two regimes (OR =1.39, 95% CI: 0.67 to 2.89).
Split dose PEG seems to be more superior to single dose for children undergoing colonoscopy. However, considering that the number of included RCTs are very limited, more related studies on this issue are needed in the future.
聚乙二醇（PEG）已广泛用于肠道准备。然而，单剂量和分剂量PEG用于儿童结肠镜检查肠道准备的疗效和安全性仍不明确，有必要评估单剂量和分剂量PEG在儿童人群肠道准备中的作用。
系统检索截至2019年9月1日的PubMed等数据库。纳入单剂量和分剂量PEG用于儿童结肠镜检查肠道准备的随机对照试验（RCT）。基于异质性，使用随机效应或固定效应模型对数据进行合成。结果以Mantel-Haenszel式比值比（OR）或平均差（MD）及95%置信区间（95%CI）表示。
纳入4项RCT，共249名儿童。单剂量和分剂量PEG用于肠道准备的疗效无显著差异（OR =0.36，95%CI：-0.12至1.10）。分剂量PEG用于肠道准备的可接受性显著高于单剂量（OR =0.50，95%CI：0.29至0.85）；分剂量PEG用于肠道准备时恶心的发生率显著低于单剂量（OR =2.1，95%CI：1.29至3.42）；两种方案在腹痛发生率上无显著差异（OR =1.39，95%CI：0.67至2.89）。
对于接受结肠镜检查的儿童，分剂量PEG似乎比单剂量更具优势。然而，考虑到纳入的RCT数量非常有限，未来需要更多关于此问题的相关研究。
