Tezuka H, Sawada H, Sakoda H, Itoh K, Nishikori M, Amagai T, Uchino H, Mori K J
First Division of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Exp Hematol. 1988 Aug;16(7):609-12.
Graft rejection is one of the major obstacles to successful bone marrow transplantation (BMT). If resistance to marrow grafting could be avoided, BMT could be used widely in treatment of hematological and immunological disorders. There has been evidence that natural killer (NK) cells play a major role in genetic resistance to BMT and that macrophages are also involved in genetic resistance. Agents toxic to macrophages such as silica and carrageenan have been found to have a suppressive effect on genetic resistance to BMT. Parenteral fat emulsions are known to accumulate in macrophages and to impair various functions of macrophages and those of the reticuloendothelial system. We show here that the administration of a fat emulsion, Intralipos 20%, to recipient mice can suppress genetic resistance to bone marrow grafts and NK cell activity probably through the impairment of the macrophage function. The administration of the fat emulsion might be a new tactic in conditioning protocols for human BMT in the future.
移植物排斥是成功进行骨髓移植（BMT）的主要障碍之一。如果能够避免对骨髓移植的抵抗，BMT就可以广泛用于治疗血液学和免疫学疾病。有证据表明，自然杀伤（NK）细胞在对BMT的遗传抵抗中起主要作用，巨噬细胞也参与遗传抵抗。已发现对巨噬细胞有毒的物质，如二氧化硅和角叉菜胶，对BMT的遗传抵抗有抑制作用。已知胃肠外脂肪乳剂会在巨噬细胞中蓄积，并损害巨噬细胞以及网状内皮系统的各种功能。我们在此表明，给受体小鼠注射20%英脱利匹特脂肪乳剂可能通过损害巨噬细胞功能来抑制对骨髓移植的遗传抵抗和NK细胞活性。脂肪乳剂的注射可能是未来人类BMT预处理方案中的一种新策略。
