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显微镜辅助下经鼻唇沟入路内镜下垂体瘤治疗的研究

A study on sublabial transsphenoidal treatment of pituitary tumor under microscope with aid of endoscope.

作者信息

Pak Yunchol, Yang Xuejun, Kim Yongdok, Jong Chanhong, Kim Haksong, Lee Namhyok, Kim Songgun, Kim Yongchol

机构信息

Department of Neurosurgery, Pyongyang Medical School Hospital, Kim Il Sung General University, Pyongyang, Democratic People's Republic of Korea.

Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, China.

出版信息

Chin Neurosurg J. 2018 Sep 3;4:22. doi: 10.1186/s41016-018-0130-y. eCollection 2018.

DOI:10.1186/s41016-018-0130-y
PMID:32922883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7398249/
Abstract

BACKGROUND

A pituitary tumor is a tumor with a high incidence among brain tumors. Microscopic traditional STT approach with aid of endoscope has a high therapeutic effect and few complications.

METHODS

The authors reviewed 146 patients who underwent STT resection of sellar masses between January 1, 2006, and December 31, 2013. From this group, 40 patients who underwent microscopic STT surgery with aid of endoscope were included in the study. In this series, there were many nonfunctional and Growth Hormone(GH) secreting adenoma. In the study group, tumor size ranged from 60 to 79 mm in 3 cases. Pathophysiological studies, tumor sizes, clinical outcomes, extent of resection, visual function and complication were estimated.

RESULTS

In our study, gross-total resection(GTR) was achieved in 33 patients (82.5%), subtotal in 3 (7.5%), and partial in 4 (10%). Visual acuity were improved in 82.1%, while 17.9% were unchanged. Visual fields were improved in 81.2%. No deaths occurred in this cohort of patients.

CONCLUSIONS

Pituitary adenoma surgery under microscope with aid of endoscope is an effective treatment method, which results in high (> 90%) rates of resection. It is not associated with high rates of major complications and is safe when performed by experienced surgeons.

摘要

背景

垂体瘤是脑肿瘤中发病率较高的一种肿瘤。在内窥镜辅助下的显微镜下传统经蝶窦手术(STT)具有较高的治疗效果且并发症较少。

方法

作者回顾了2006年1月1日至2013年12月31日期间接受蝶鞍区肿块STT切除术的146例患者。从该组中,40例在内窥镜辅助下接受显微镜下STT手术的患者被纳入研究。在这个系列中,有许多无功能和分泌生长激素(GH)的腺瘤。在研究组中,3例肿瘤大小在60至79毫米之间。评估了病理生理学研究、肿瘤大小、临床结果、切除范围、视力和并发症。

结果

在我们的研究中,33例患者(82.5%)实现了全切除(GTR),3例(7.5%)次全切除,4例(10%)部分切除。视力改善的患者占82.1%,而17.9%的患者视力无变化。视野改善的患者占81.2%。该组患者无死亡病例。

结论

在内窥镜辅助下的显微镜下垂体腺瘤手术是一种有效的治疗方法,切除率高(>90%)。它与高比例的严重并发症无关,由经验丰富的外科医生进行时是安全的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559c/7398249/128bb03097e3/41016_2018_130_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559c/7398249/2e255575261a/41016_2018_130_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559c/7398249/128bb03097e3/41016_2018_130_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559c/7398249/2e255575261a/41016_2018_130_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559c/7398249/128bb03097e3/41016_2018_130_Fig2_HTML.jpg

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World Neurosurg. 2016 Dec;96:36-46. doi: 10.1016/j.wneu.2016.08.088. Epub 2016 Aug 30.
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Cavernous sinus invasion by pituitary adenomas: role of endoscopic endonasal surgery.垂体腺瘤侵犯海绵窦:鼻内镜手术的作用
J Neurosurg Sci. 2016 Dec;60(4):485-94. Epub 2016 Jun 9.
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Resection of pituitary tumors: endoscopic versus microscopic.
垂体肿瘤切除术:内镜手术与显微镜手术对比
J Neurooncol. 2016 Nov;130(2):309-317. doi: 10.1007/s11060-016-2124-y. Epub 2016 May 9.
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