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关于在初级保健实践中实施药物遗传学所面临挑战的文献综述。

Literature Review Concerning the Challenges of Implementing Pharmacogenetics in Primary Care Practice.

作者信息

Omer Mohamed S

机构信息

Pharmacology, The Ohio State University College of Pharmacy, Columbus, USA.

出版信息

Cureus. 2020 Aug 8;12(8):e9616. doi: 10.7759/cureus.9616.

Abstract

Since President Obama signed the Precision Medicine Initiative in 2015, endeavors to integrate pharmacogenetics in clinical practice and psychiatric care have been evolving rapidly. The nature of general practice and psychiatric medicine, including psychopharmacotherapy and the long-term care necessary for chronic diseases, renders these fields in desperate need of the implementation of pharmacogenetics. This article presents some of the challenges facing pharmacogenetics implementation in family medicine and psychiatric care. Reputable research websites were used to extract papers, data, and lectures concerning this topic. The results reveal that three main challenges are facing this integration: the evaluation of pharmacogenetic testing in general and psychiatric practice, cost-effectiveness, and regulatory burdens. Although considerable advances are being made to address these issues, it is time to gather these efforts under one umbrella to create guidelines based on previous and upcoming research.

摘要

自2015年奥巴马总统签署精准医学计划以来,将药物遗传学整合到临床实践和精神科护理中的努力一直在迅速发展。全科医学和精神医学的性质,包括精神药物治疗和慢性病所需的长期护理,使得这些领域迫切需要实施药物遗传学。本文介绍了在家庭医学和精神科护理中实施药物遗传学所面临的一些挑战。利用知名研究网站提取了有关该主题的论文、数据和讲座。结果表明,这种整合面临三个主要挑战:一般和精神科实践中药物遗传学检测的评估、成本效益和监管负担。尽管在解决这些问题方面取得了相当大的进展,但现在是时候将这些努力整合在一起,根据以往和即将开展的研究制定指导方针了。

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Clinical implementation of pharmacogenetics.药物遗传学的临床应用
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Implementing Precision Medicine: The Ethical Challenges.实施精准医学:伦理挑战。
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本文引用的文献

1
Analytical validation of a psychiatric pharmacogenomic test.一种精神科药物基因组学检测的分析验证
Per Med. 2018 May 1;15(3):189-197. doi: 10.2217/pme-2017-0094. Epub 2018 Feb 7.
5
Psychiatric pharmacogenomic testing in clinical practice.临床实践中的精神科药物基因组学检测
Dialogues Clin Neurosci. 2010;12(1):69-76. doi: 10.31887/DCNS.2010.12.1/dmrazek.

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