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The Daniel K. Inouye College of Pharmacy Scripts: Precision Medicine Through the Use of Pharmacogenomics: Current Status and Barriers to Implementation.丹尼尔·K·伊努耶药学院文稿:通过药物基因组学实现精准医学:现状与实施障碍
Hawaii J Med Public Health. 2017 Sep;76(9):265-269.
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本文引用的文献

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Genetic testing insurance coverage trends: a review of publicly available policies from the largest US payers.基因检测保险覆盖趋势:对美国最大支付方公开政策的综述
Per Med. 2013 May;10(3):235-243. doi: 10.2217/pme.13.9.
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Role of genetic testing in patients undergoing percutaneous coronary intervention.基因检测在接受经皮冠状动脉介入治疗患者中的作用。
Expert Rev Clin Pharmacol. 2018 Feb;11(2):151-164. doi: 10.1080/17512433.2017.1353909. Epub 2017 Oct 12.
3
The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.IGNITE药物遗传学工作组:在现实环境中通过药物遗传学实施建立证据的契机。
Clin Transl Sci. 2017 May;10(3):143-146. doi: 10.1111/cts.12456. Epub 2017 Mar 14.
4
Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation.用于临床应用的CYP450基因遗传变异分析
PLoS One. 2017 Jan 3;12(1):e0169233. doi: 10.1371/journal.pone.0169233. eCollection 2017.
5
Genetics in the Clinical Decision of Antiplatelet Treatment.抗血小板治疗临床决策中的遗传学因素
Curr Pharm Des. 2017;23(9):1307-1314. doi: 10.2174/1381612822666161226152529.
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CYP2C19 and CYP2D6 genotypes in Pacific peoples.太平洋人群中的CYP2C19和CYP2D6基因分型
Br J Clin Pharmacol. 2016 Nov;82(5):1303-1307. doi: 10.1111/bcp.13045. Epub 2016 Aug 26.
7
Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel.CYP2C19 代谢酶表型对接受普拉格雷与氯吡格雷治疗的 ACS 患者的影响。
J Am Coll Cardiol. 2016 Mar 1;67(8):936-947. doi: 10.1016/j.jacc.2015.12.036.
8
A randomized controlled trial to assess the efficacy and safety of doubling dose clopidogrel versus ticagrelor for the treatment of acute coronary syndrome in patients with CYP2C19*2 homozygotes.一项随机对照试验,旨在评估双倍剂量氯吡格雷与替格瑞洛治疗CYP2C19*2纯合子急性冠脉综合征患者的疗效和安全性。
Int J Clin Exp Med. 2015 Aug 15;8(8):13310-6. eCollection 2015.
9
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.纳武单抗与多西他赛治疗晚期鳞状细胞非小细胞肺癌的疗效比较
N Engl J Med. 2015 Jul 9;373(2):123-35. doi: 10.1056/NEJMoa1504627. Epub 2015 May 31.
10
Routine screening for CYP2C19 polymorphisms for patients being treated with clopidogrel is not recommended.不建议对正在接受氯吡格雷治疗的患者进行CYP2C19基因多态性的常规筛查。
Hawaii J Med Public Health. 2015 Jan;74(1):16-20.

丹尼尔·K·伊努耶药学院文稿:通过药物基因组学实现精准医学:现状与实施障碍

The Daniel K. Inouye College of Pharmacy Scripts: Precision Medicine Through the Use of Pharmacogenomics: Current Status and Barriers to Implementation.

作者信息

Ciarleglio Anita E, Ma Carolyn

机构信息

Assistant Specialist, University of Hawai'i at Hilo, Daniel K. Inouye College of Pharmacy, Hilo, HI.

Dr. Ma is a Board Certified Oncology Pharmacy Specialist with experiences in health systems administration and pharmacy academe.

出版信息

Hawaii J Med Public Health. 2017 Sep;76(9):265-269.

PMID:28900583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5592383/
Abstract

The precision medicine initiative brought forth by President Barack Obama in 2015 is an important step on the journey to truly personalized medicine. A broad knowledge and understanding of the implications of the pharmacogenomic literature will be critical to the achievement of this goal. While a great amount of data has been published in the areas of pharmacogenomics and pharmacogenetics, there are still relatively few instances in which the need for clinical intervention can be stated without doubt, and which are widely accepted and practiced by the medical community. As our knowledge base rapidly expands, issues such as insurance reimbursement for genetic testing and education of the health care workforce will be paramount to achieving the goal of precision medicine for all patients.

摘要

巴拉克·奥巴马总统于2015年提出的精准医疗计划是迈向真正个性化医疗征程中的重要一步。对药物基因组学文献的广泛了解和认识对于实现这一目标至关重要。虽然在药物基因组学和药物遗传学领域已经发表了大量数据,但仍有相对较少的情况能够毫无疑问地表明临床干预的必要性,并且被医学界广泛接受和实践。随着我们的知识库迅速扩展,基因检测的保险报销以及医疗保健人员的教育等问题对于实现所有患者的精准医疗目标至关重要。