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氟考昔诱导的肺纤维化罕见病例

A Rare Case of Flavocoxid-Induced Pulmonary Fibrosis.

作者信息

Drekolias Dimitrios, Gadela Naga Vaishnavi, Krupka Philip, Broess Jennifer, Jacob Jason

机构信息

Internal Medicine, University of Connecticut, Farmington, USA.

Internal Medicine, Rush University, Chicago, USA.

出版信息

Cureus. 2020 Aug 8;12(8):e9617. doi: 10.7759/cureus.9617.

Abstract

Pulmonary fibrosis is a chronic progressive interstitial lung disease characterized by repetitive cycles of epithelial cell injury and dysregulated repair. Although most cases of pulmonary fibrosis are idiopathic, a detailed history that includes medications, comorbidities, tobacco use, environmental exposures, and family history should be taken to rule out secondary etiology. We present a case of flavocoxid-induced pulmonary toxicity which progressed from hypersensitivity pneumonitis to pulmonary fibrosis even after discontinuation of the offending drug.

摘要

肺纤维化是一种慢性进行性间质性肺疾病,其特征为上皮细胞损伤和修复失调的反复循环。虽然大多数肺纤维化病例是特发性的,但应详细询问病史,包括用药情况、合并症、吸烟史、环境暴露史和家族史,以排除继发性病因。我们报告一例由黄氧化素引起的肺毒性病例,即使停用致病药物后,仍从过敏性肺炎进展为肺纤维化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd5/7478690/117d3a025459/cureus-0012-00000009617-i01.jpg

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