Drekolias Dimitrios, Gadela Naga Vaishnavi, Krupka Philip, Broess Jennifer, Jacob Jason
Internal Medicine, University of Connecticut, Farmington, USA.
Internal Medicine, Rush University, Chicago, USA.
Cureus. 2020 Aug 8;12(8):e9617. doi: 10.7759/cureus.9617.
Pulmonary fibrosis is a chronic progressive interstitial lung disease characterized by repetitive cycles of epithelial cell injury and dysregulated repair. Although most cases of pulmonary fibrosis are idiopathic, a detailed history that includes medications, comorbidities, tobacco use, environmental exposures, and family history should be taken to rule out secondary etiology. We present a case of flavocoxid-induced pulmonary toxicity which progressed from hypersensitivity pneumonitis to pulmonary fibrosis even after discontinuation of the offending drug.
肺纤维化是一种慢性进行性间质性肺疾病，其特征为上皮细胞损伤和修复失调的反复循环。虽然大多数肺纤维化病例是特发性的，但应详细询问病史，包括用药情况、合并症、吸烟史、环境暴露史和家族史，以排除继发性病因。我们报告一例由黄氧化素引起的肺毒性病例，即使停用致病药物后，仍从过敏性肺炎进展为肺纤维化。
