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辅酶 Q10 防晒霜可预防小鼠紫外线诱导的皮肤损伤进展。

Coenzyme Q Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice.

机构信息

Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong, China.

Dongguan Institute for Food and Drug Control, Dongguan, Guangdong, China.

出版信息

Biomed Res Int. 2020 Aug 19;2020:9039843. doi: 10.1155/2020/9039843. eCollection 2020.

DOI:10.1155/2020/9039843
PMID:32923487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7453241/
Abstract

The level of sun ultraviolet ray reaching the surface of the earth is increasing severely due to the rapid development of the society and environmental destruction. Excessive exposure to ultraviolet radiation causes skin damage and photoaging. Therefore, it is emerged to develop effective sunscreen to prevent ultraviolet-induced skin damage. This study was aimed at investigating the effects of Coenzyme Q (CoQ) sunscreen on the prevention of ultraviolet B radiation- (UVB-) induced mouse skin damage. Three-month-old female mice were used, and they were randomly divided into four groups: control, model, CoQ, and titanium dioxide (TiO; positive control) groups. Our results showed that body weight, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and DNA (cytosine-5)-methyltransferase 1 (DNMT1) protein expression were significantly decreased, while malondialdehyde (MDA) activity and metalloproteinase-1 (MMP-1) level were increased in UVB-treated mice. Besides, the stratum corneum was shed from the skin surface in the model group compared with the control group. In contrast, CoQ10 sunscreen prevented from UVB-induced skin damage, as well as reversing SOD, GSH-Px, and MDA activities, and MMP-1 and DNMT1 levels. Taken together, the current study provided further evidence on the prevention of UVB-induced skin damage by CoQ and its underlying mechanisms.

摘要

由于社会的快速发展和环境破坏，到达地球表面的太阳紫外线水平严重增加。过度暴露于紫外线辐射会导致皮肤损伤和光老化。因此，开发有效的防晒霜来预防紫外线引起的皮肤损伤已迫在眉睫。本研究旨在探讨辅酶 Q（CoQ）防晒霜预防紫外线 B 辐射（UVB）诱导的小鼠皮肤损伤的作用。使用三个月大的雌性小鼠，并将其随机分为四组：对照组、模型组、CoQ 组和二氧化钛（TiO；阳性对照）组。我们的结果表明，体重、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性以及 DNA（胞嘧啶-5）-甲基转移酶 1（DNMT1）蛋白表达显著降低，而丙二醛（MDA）活性和基质金属蛋白酶-1（MMP-1）水平在 UVB 处理的小鼠中增加。此外，与对照组相比，模型组皮肤表面的角质层从皮肤表面脱落。相比之下，CoQ10 防晒霜可预防 UVB 诱导的皮肤损伤，并逆转 SOD、GSH-Px 和 MDA 活性以及 MMP-1 和 DNMT1 水平。总之，本研究进一步证明了 CoQ 预防 UVB 诱导的皮肤损伤的作用及其潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/e433eefba4a7/BMRI2020-9039843.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/7a5148621584/BMRI2020-9039843.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/199e831a6f5b/BMRI2020-9039843.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/fa77fe21ae70/BMRI2020-9039843.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/bcc96201ddc3/BMRI2020-9039843.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/b24263bc7d42/BMRI2020-9039843.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/e433eefba4a7/BMRI2020-9039843.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/7a5148621584/BMRI2020-9039843.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/199e831a6f5b/BMRI2020-9039843.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/fa77fe21ae70/BMRI2020-9039843.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/bcc96201ddc3/BMRI2020-9039843.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/b24263bc7d42/BMRI2020-9039843.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f320/7453241/e433eefba4a7/BMRI2020-9039843.006.jpg

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