Department of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Nutr Rev. 2013 Mar;71(3):180-8. doi: 10.1111/nure.12011. Epub 2013 Jan 30.
Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration. A deficiency in either its bioavailability or its biosynthesis can lead to one of several disease states. Primary deficiency has been well described and results from mutations in genes involved in CoQ10 biosynthesis. Secondary deficiency may be linked to hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), which are used for the treatment of hypercholesterolemia. Dietary contributions of CoQ10 are very small, but supplementation is effective in increasing plasma CoQ10 levels. It has been clearly demonstrated that treatment with CoQ10 is effective in numerous disorders and deficiency states and that supplementation has a favorable outcome. However, CoQ10 is not routinely prescribed in clinical practice. This review explores primary as well as statin-induced secondary deficiency and provides an overview of the benefits of CoQ10 supplementation.
辅酶 Q10（CoQ10）是动物细胞从头合成的唯一脂溶性抗氧化剂。它存在于细胞膜中，特别以其在有氧细胞呼吸中线粒体膜中的电子传递链中的作用而闻名。其生物利用度或生物合成的缺乏都可能导致几种疾病状态之一。主要缺乏症已有很好的描述，是由于参与 CoQ10 生物合成的基因突变所致。继发性缺乏可能与羟甲基戊二酰辅酶 A（HMG-CoA）还原酶抑制剂（他汀类药物）有关，这些药物用于治疗高胆固醇血症。CoQ10 的膳食摄入量非常小，但补充剂可有效增加血浆 CoQ10 水平。已经清楚地表明，用 CoQ10 治疗对许多疾病和缺乏状态有效，并且补充剂有良好的效果。但是，CoQ10 在临床实践中并未常规使用。这篇综述探讨了原发性和他汀类药物引起的继发性缺乏，并概述了 CoQ10 补充的益处。
