WNT-Activated Medulloblastomas With Hybrid Molecular Subtypes.
作者信息
Helgager Jeffrey, Pytel Peter, Vasudevaraja Varshini, Lee Eudocia Q, Snuderl Matija, Iorgulescu J Bryan, Ligon Keith L
机构信息
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Department of Pathology, University of Chicago Medical Center, Chicago, IL.
出版信息
JCO Precis Oncol. 2020 Apr 14;4. doi: 10.1200/PO.19.00332. eCollection 2020.
Abstract
摘要
相似文献
1
WNT-Activated Medulloblastomas With Hybrid Molecular Subtypes.具有混合分子亚型的WNT激活型髓母细胞瘤
JCO Precis Oncol. 2020 Apr 14;4. doi: 10.1200/PO.19.00332. eCollection 2020.
2
Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype.成神经管细胞瘤的影像学标志物：其 MRI 影像表型可用于鉴定遗传亚型。
AJNR Am J Neuroradiol. 2017 Oct;38(10):1892-1898. doi: 10.3174/ajnr.A5313. Epub 2017 Aug 10.
3
Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect Wnt activated tumours.髓母细胞瘤的分子分层：组织学和遗传学方法检测 Wnt 激活肿瘤的比较。
Neuropathol Appl Neurobiol. 2015 Feb;41(2):135-44. doi: 10.1111/nan.12161.
4
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.Wnt/无翅通路激活和6号染色体缺失是一类预后良好的髓母细胞瘤独特分子亚组的特征。
Cell Cycle. 2006 Nov;5(22):2666-70. doi: 10.4161/cc.5.22.3446. Epub 2006 Nov 15.
5
Differential expression of somatostatin receptors, P44/42 MAPK, and mTOR activation in medulloblastomas and primitive neuroectodermal tumors.髓母细胞瘤和原始神经外胚层肿瘤中生长抑素受体、P44/42丝裂原活化蛋白激酶及雷帕霉素靶蛋白激活的差异表达
Appl Immunohistochem Mol Morphol. 2013 Dec;21(6):532-8. doi: 10.1097/PAI.0b013e3182813724.
6
Pediatric Posterior Fossa Medulloblastoma: The Role of Diffusion Imaging in Identifying Molecular Groups.小儿后颅窝髓母细胞瘤：扩散成像在识别分子亚群中的作用。
J Neuroimaging. 2020 Jul;30(4):503-511. doi: 10.1111/jon.12704. Epub 2020 Jun 12.
7
Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas.小儿髓母细胞瘤组织病理学亚型的免疫组织化学分析
Pathol Int. 2003 Feb;53(2):67-73. doi: 10.1046/j.1440-1827.2003.01444.x.
8
[Molecular subgrouping and characterization analysis of medulloblastomas in a cohort of Japanese patients].[日本患者队列中髓母细胞瘤的分子亚组分类及特征分析]
No Shinkei Geka. 2015 Feb;43(2):117-25. doi: 10.11477/mf.1436202965.
9
Advances in molecular targets for the treatment of medulloblastomas.髓母细胞瘤治疗分子靶点的进展
Clin Invest Med. 2012 Oct 6;35(5):E246. doi: 10.25011/cim.v35i5.18697.
10
DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas.DNA 甲基化分析是小儿 WNT 激活型髓母细胞瘤分子验证的首选方法。
Neuro Oncol. 2019 Feb 14;21(2):214-221. doi: 10.1093/neuonc/noy155.
引用本文的文献
1
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.磷酸二酯酶 10A 单倍不足通过激活 PI3K/AKT 信号而不依赖于 PTEN 诱导侵袭性神经胶质瘤表型。
Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123.
2
Clinico-Radiological Outcomes in WNT-Subgroup Medulloblastoma.WNT亚组髓母细胞瘤的临床放射学结果
Diagnostics (Basel). 2024 Feb 7;14(4):358. doi: 10.3390/diagnostics14040358.
3
A CTNNB1-altered medulloblastoma shows the immunophenotypic, DNA methylation and transcriptomic profiles of SHH-activated, and not WNT-activated, medulloblastoma.CTNNB1 改变的髓母细胞瘤显示出 SHH 激活而非 WNT 激活的髓母细胞瘤的免疫表型、DNA 甲基化和转录组特征。
Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12815. doi: 10.1111/nan.12815. Epub 2022 Mar 30.
4
The Role of Neurodevelopmental Pathways in Brain Tumors.神经发育通路在脑肿瘤中的作用。
Front Cell Dev Biol. 2021 Apr 27;9:659055. doi: 10.3389/fcell.2021.659055. eCollection 2021.
本文引用的文献
1
Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis.索尼替尼和维莫德吉治疗儿科和成人 MB 患者的 I 期和 II 期临床试验：系统评价和荟萃分析。
Acta Neuropathol Commun. 2019 Jul 30;7(1):123. doi: 10.1186/s40478-019-0773-8.
2
Resolving medulloblastoma cellular architecture by single-cell genomics.通过单细胞基因组学解析成神经管细胞瘤的细胞结构。
Nature. 2019 Aug;572(7767):74-79. doi: 10.1038/s41586-019-1434-6. Epub 2019 Jul 24.
3
Integrating a Large Next-Generation Sequencing Panel into the Clinical Diagnosis of Gliomas Provides a Comprehensive Platform for Classification from FFPE Tissue or Smear Preparations.将大型下一代测序面板整合到胶质细胞瘤的临床诊断中，为从 FFPE 组织或涂片制备物进行分类提供了一个全面的平台。
J Neuropathol Exp Neurol. 2019 Mar 1;78(3):257-267. doi: 10.1093/jnen/nly130.
4
Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.WNT激活的髓母细胞瘤的深度测序揭示了继发性SHH通路激活。
Acta Neuropathol. 2018 Apr;135(4):635-638. doi: 10.1007/s00401-018-1819-x. Epub 2018 Feb 12.
5
The whole-genome landscape of medulloblastoma subtypes.髓母细胞瘤亚型的全基因组图谱。
Nature. 2017 Jul 19;547(7663):311-317. doi: 10.1038/nature22973.
6
Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer.OncoPanel验证：一种用于检测癌症体细胞变异的靶向新一代测序分析方法
Arch Pathol Lab Med. 2017 Jun;141(6):751-758. doi: 10.5858/arpa.2016-0527-OA. Epub 2017 Mar 3.
7
Spatial heterogeneity in medulloblastoma.髓母细胞瘤中的空间异质性。
Nat Genet. 2017 May;49(5):780-788. doi: 10.1038/ng.3838. Epub 2017 Apr 10.
8
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.FBW7抑制导致髓母细胞瘤中SOX9稳定并增加恶性程度。
EMBO J. 2016 Oct 17;35(20):2192-2212. doi: 10.15252/embj.201693889. Epub 2016 Sep 13.
9
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.维莫德吉对复发性音猬因子亚组髓母细胞瘤具有靶向疗效：来自儿科脑肿瘤协作组II期研究PBTC-025B和PBTC-032的结果
J Clin Oncol. 2015 Aug 20;33(24):2646-54. doi: 10.1200/JCO.2014.60.1591. Epub 2015 Jul 13.
10
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.SHH 型髓母细胞瘤的基因组测序预测了 smoothened 抑制与基因型相关的反应。
Cancer Cell. 2014 Mar 17;25(3):393-405. doi: 10.1016/j.ccr.2014.02.004.
Zotero 插件