Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
作者信息
Iorgulescu J Bryan, Van Ziffle Jessica, Stevers Meredith, Grenert James P, Bastian Boris C, Chavez Lukas, Stichel Damian, Buchhalter Ivo, Samuel David, Nicolaides Theodore, Banerjee Anuradha, Mueller Sabine, Gupta Nalin, Tihan Tarik, Bollen Andrew W, Northcott Paul A, Kool Marcel, Pfister Stefan, Korshunov Andrey, Perry Arie, Solomon David A
机构信息
Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, San Francisco, CA, 94143, USA.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Acta Neuropathol. 2018 Apr;135(4):635-638. doi: 10.1007/s00401-018-1819-x. Epub 2018 Feb 12.
Abstract
摘要
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本文引用的文献
1
The whole-genome landscape of medulloblastoma subtypes.髓母细胞瘤亚型的全基因组图谱。
Nature. 2017 Jul 19;547(7663):311-317. doi: 10.1038/nature22973.
2
Intertumoral Heterogeneity within Medulloblastoma Subgroups.髓母细胞瘤亚组内的肿瘤间异质性。
Cancer Cell. 2017 Jun 12;31(6):737-754.e6. doi: 10.1016/j.ccell.2017.05.005.
3
Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.对儿科神经肿瘤患者进行靶向二代测序可改善诊断、识别致病性种系突变并指导靶向治疗。
Neuro Oncol. 2017 May 1;19(5):699-709. doi: 10.1093/neuonc/now254.
4
Spatial heterogeneity in medulloblastoma.髓母细胞瘤中的空间异质性。
Nat Genet. 2017 May;49(5):780-788. doi: 10.1038/ng.3838. Epub 2017 Apr 10.
5
Dissecting the genomic complexity underlying medulloblastoma.解析髓母细胞瘤的基因组复杂性。
Nature. 2012 Aug 2;488(7409):100-5. doi: 10.1038/nature11284.
6
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.1000 例髓母细胞瘤全基因组亚组特异性结构变异。
Nature. 2012 Aug 2;488(7409):49-56. doi: 10.1038/nature11327.
7
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.髓母细胞瘤外显子组测序揭示了亚型特异性的体细胞突变。
Nature. 2012 Aug 2;488(7409):106-10. doi: 10.1038/nature11329.
8
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.髓母细胞瘤的分子亚型：WNT、SHH、Group 3 和 Group 4 髓母细胞瘤的转录组、遗传异常和临床数据的国际荟萃分析。
Acta Neuropathol. 2012 Apr;123(4):473-84. doi: 10.1007/s00401-012-0958-8. Epub 2012 Feb 23.
9
Medulloblastoma comprises four distinct molecular variants.髓母细胞瘤包含四个不同的分子亚型。
J Clin Oncol. 2011 Apr 10;29(11):1408-14. doi: 10.1200/JCO.2009.27.4324. Epub 2010 Sep 7.
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