Dal Lin Carlo, Tona Francesco, Osto Elena
Department of Cardiac, Thoracic and Vascular Sciences, Padua University-Hospital, Padua, Italy.
University and University Hospital Zurich, Institute of Clinical Chemistry, Zurich, Switzerland.
Vasc Biol. 2019 Aug 15;1(1):H83-H88. doi: 10.1530/VB-19-0023. eCollection 2019.
The heart and the immune system are highly integrated systems cross-talking through cytokines, hormones and neurotransmitters. Their balance can be altered by numerous physical or psychological stressors leading to the onset of inflammation, endothelial dysfunction and tissue damage. Here, we review the main players and mechanisms involved in the field. A new research paradigm, which considers also novel contributors, like endothelial cells, is needed to better understand the pathophysiology of immune-mediated cardiovascular disorders and beyond.
心脏和免疫系统是高度整合的系统，通过细胞因子、激素和神经递质相互作用。许多身体或心理应激源可改变它们之间的平衡，导致炎症、内皮功能障碍和组织损伤的发生。在此，我们综述该领域的主要作用因素和机制。需要一种新的研究范式，该范式还要考虑像内皮细胞这样的新因素，以更好地理解免疫介导的心血管疾病及其他疾病的病理生理学。
