[N-甲基-N-亚硝基脲在正常细胞和肿瘤细胞中的代谢激活作用]
[Metabolic activation of N-methyl-N-nitrosourea in normal and tumor cells].
作者信息
Abakumova O Iu, Kutsenko N G, Lerman M I
出版信息
Biokhimiia. 1978 Nov;43(11):2092-9.
PMID:32924
Abstract
N-methyl-N-nitrosourea is metabolised by mouse liver microsomes yielding highly reactive product(s) capable of alkylating cellular macromolecules. Based on cofactor requirement (NADPH, oxygen), inhibition (NaN3) and induction by phenobarbital, 3,4-benz(a)pyrene, and MNU, the reaction is cytochrome P-450-dependent. Analysis of the kinetics and dose dependence of alkylation in vivo and in tissue homogenates confirms the fact that MNU must undergo metabolic activation in vivo.
摘要
N-甲基-N-亚硝基脲在小鼠肝脏微粒体中代谢，产生能够烷基化细胞大分子的高活性产物。根据辅因子需求（NADPH、氧气）、抑制作用（叠氮化钠）以及苯巴比妥、3,4-苯并(a)芘和N-甲基-N-亚硝基脲的诱导作用，该反应是细胞色素P-450依赖性的。体内和组织匀浆中烷基化动力学和剂量依赖性分析证实了N-甲基-N-亚硝基脲在体内必须经过代谢活化这一事实。
相似文献
1
[Metabolic activation of N-methyl-N-nitrosourea in normal and tumor cells].[N-甲基-N-亚硝基脲在正常细胞和肿瘤细胞中的代谢激活作用]
Biokhimiia. 1978 Nov;43(11):2092-9.
2
[Metabolic activation of N-methyl-N-nitrosourea in tumor cells].[肿瘤细胞中N-甲基-N-亚硝基脲的代谢活化]
Vopr Med Khim. 1981 May-Jun;27(3):383-7.
3
Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.N,N',N''-三乙烯硫代磷酰胺的生物转化：氧化脱硫生成N,N',N''-三乙烯磷酰胺，并与苯巴比妥诱导的肝P-450单加氧酶的自杀失活相关。
Cancer Res. 1990 Feb 1;50(3):464-71.
4
Mechanism for isaxonine hepatitis. I. Metabolic activation by mouse and human cytochrome P-450.异西半胱氨酸肝炎的机制。I. 小鼠和人细胞色素P-450的代谢激活作用。
J Pharmacol Exp Ther. 1984 Jun;229(3):845-50.
5
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens].[异生素和化学致癌物影响下的微粒体DNA合成加速]
Biokhimiia. 1979 Apr;44(4):699-704.
6
Binding of labeled N-methyl N-nitrosourea to macromolecules of squamous and glandular stomach of rats.标记的N-甲基-N-亚硝基脲与大鼠鳞状胃和腺胃大分子的结合。
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):373-6.
7
Phencyclidine iminium ion. NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P-450.苯环己哌啶亚胺离子。NADPH 依赖性代谢、与大分子的共价结合以及细胞色素 P-450 的失活。
Drug Metab Dispos. 1987 Jul-Aug;15(4):485-90.
8
9
Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.微粒体谷胱甘肽S-转移酶和细胞色素P450单加氧酶催化抗癌药物1,3-双(2-氯乙基)-1-亚硝基脲的脱亚硝化反应。
Arch Biochem Biophys. 1993 Dec;307(2):369-78. doi: 10.1006/abbi.1993.1602.
10
Electrochemical investigations on the oxygen activation by cytochrome P-450.细胞色素P-450对氧激活的电化学研究。
Acta Biol Med Ger. 1979;38(2-3):503-9.
Zotero 插件