[Metabolism of N-methyl-N-nitrosourea in various mouse tissues under inhibition of protein and nucleic acid synthesis].

The contribution of C1-pool and antimetabolite utilization to modification (labeling) of macromolecules of various mouse tissues after a single injection of 1-14C-methylnitrosourea was studied, using inhibitors of protein and nucleic acid synthesis. It was shown that about 50% of radioactivity found in the proteins, lipoproteins and DNA (but not in RNA) might be supplied by the C1-pool and/or through utilization of radioactive metabolites in the first 3-6 hours following the injection of 1-14C-methylnitrosourea. The data obtained allow to evaluete the degree of alkylation of macromolecules in various organs and tissues.