Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Division of Maternal Fetal Medicine, Women and Newborns Clinical Program, Intermountain Healthcare, Program for Addiction Research, Clinical Care, Knowledge and Advocacy (PARCKA), Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, and the Maternal and Infant Health Program, Utah Department of Health, Salt Lake City, Utah.
Obstet Gynecol. 2020 Oct;136(4):645-653. doi: 10.1097/AOG.0000000000003988.
To estimate the proportion of accidental drug-related deaths and suicides classified as pregnancy-related from 2013 to 2014 (preimplementation of standardized criteria) and 2015 to 2016 (postimplementation).
Based on Centers for Disease Control and Prevention pregnancy-related death criteria, the Utah Perinatal Mortality Review Committee developed a standardized evaluation tool to assess accidental drug-related death and suicide beginning in 2015. We performed a retrospective case review of all pregnancy-associated deaths (those occurring during pregnancy or 1 year postpartum for any reason) and pregnancy-related deaths (those directly attributable to the pregnancy or postpartum events) evaluated by Utah's Perinatal Mortality Review Committee from 2013 to 2016. We compared the proportion of accidental drug-related deaths and suicides meeting pregnancy-related criteria preimplementation and postimplementation of a standardized criteria checklist tool using Fisher's exact test. We assessed the change in pregnancy-related mortality ratio in Utah from 2013 to 2014 and 2015 to 2016 using test of trend.
From 2013 to 2016, there were 80 pregnancy-associated deaths in Utah (2013-2014: n=40; 2015-2016: n=40), and 41 (51%) were pregnancy-related (2013-2014: n=15, 2015-2016: n=26). In 2013-2014 (preimplementation), 12 women died of drug-related deaths or suicides, and only two of these deaths were deemed pregnancy-related (17%). In 2015-2016 (postimplementation), 18 women died of drug-related deaths or suicide, and 94% (n=17/18) of these deaths met one or more of the pregnancy-related criteria on the checklist (P<.001). From 2013 to 2014 to 2015-2016, Utah's overall pregnancy-related mortality ratio more than doubled, from 11.8 of 100,000 to 25.7 of 100,000 (P=.08).
After application of standardized criteria, the Utah Perinatal Mortality Review Committee determined that pregnancy itself was the inciting event leading to the majority of accidental drug-related deaths or suicides among pregnant and postpartum women. Other maternal mortality review committees may consider a standardized approach to assessing perinatal suicides and accidental drug-related deaths.
评估 2013 年至 2014 年(实施标准化标准前)和 2015 年至 2016 年(实施后)与意外药物相关的死亡和自杀中与妊娠相关的比例。
根据疾病控制和预防中心的妊娠相关死亡标准,犹他州围产期死亡率审查委员会开发了一种标准化评估工具,从 2015 年开始评估与意外药物相关的死亡和自杀。我们对犹他州围产期死亡率审查委员会评估的所有与妊娠相关的死亡(妊娠期间或任何原因的产后 1 年内发生的死亡)和妊娠相关死亡(直接归因于妊娠或产后事件的死亡)进行了回顾性病例审查。我们使用 Fisher 精确检验比较了实施标准化检查表工具前后与妊娠相关的标准的意外药物相关死亡和自杀的比例。我们使用趋势检验评估了犹他州 2013 年至 2014 年和 2015 年至 2016 年的妊娠相关死亡率比的变化。
2013 年至 2016 年,犹他州有 80 例与妊娠相关的死亡(2013-2014 年:n=40;2015-2016 年:n=40),其中 41 例(51%)与妊娠相关(2013-2014 年:n=15,2015-2016 年:n=26)。2013-2014 年(实施前),有 12 名妇女死于药物相关死亡或自杀,其中只有 2 例被认为与妊娠有关(17%)。2015-2016 年(实施后),有 18 名妇女死于药物相关死亡或自杀,其中 94%(n=17/18)的死亡符合检查表上的一个或多个妊娠相关标准(P<.001)。从 2013 年至 2014 年至 2015 年至 2016 年,犹他州的整体妊娠相关死亡率翻了一番多,从每 10 万人 11.8 例增至每 10 万人 25.7 例(P=.08)。
在应用标准化标准后,犹他州围产期死亡率审查委员会确定,妊娠本身是导致妊娠和产后妇女与意外药物相关的死亡或自杀的主要原因。其他孕产妇死亡率审查委员会可能会考虑采用标准化方法评估围产期自杀和意外药物相关死亡。