Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Rehabilitation Center, Shinshu University Hospital, Matsumoto, Nagano, Japan.
Spine (Phila Pa 1976). 2020 Dec 15;45(24):E1677-E1681. doi: 10.1097/BRS.0000000000003689.
Japanese resident cohort study based on a municipal registry.
This study of a community-dwelling elderly Japanese population employed random sampling from the basic resident registry of a rural town for subject selection to investigate the differences in bone mineral density (BMD) and bone turnover markers between subjects with and without diffuse idiopathic skeletal hyperostosis (DISH).
DISH is a condition characterized by the calcification and ossification of soft tissues. Although some reports have addressed BMD in DISH, the precise status of BMD and bone metabolism in individuals with DISH remains unclear.
Eight groups based on age (50s, 60s, 70s, and 80s) and sex after random sampling from the resident registry of Obuse town were established. A total of 411 participants (202 males and 209 females) were enrolled for the evaluation of BMD and bone turnover markers. All subjects underwent a single whole-spine lateral radiographic examination for the existence of DISH. The BMD and bone turnover markers of subjects with and without DISH were analyzed for associations with the disorder using multivariate analysis.
DISH was detected in 66 (16.1%) participants in our population cohort. According to multivariate analysis, increased lumbar and hip BMD were significantly related to DISH (odds ratio: 7.47 and 22.8, respectively).
This study clarified the differences in BMD and bone turnover markers between subjects with and without DISH on a general population basis. Multivariate analysis revealed increased lumbar and hip BMD to be significantly associated with DISH, with no remarkable findings for bone turnover markers.
基于市级登记册的日本居民队列研究。
本研究对居住在农村社区的老年日本人群进行了随机抽样，从基本居民登记册中选择研究对象，以调查弥漫特发性骨肥厚（DISH）患者与非 DISH 患者之间骨密度（BMD）和骨转换标志物的差异。
DISH 是一种以软组织钙化和骨化为特征的疾病。尽管已有一些报告涉及 DISH 的 BMD，但 DISH 患者的 BMD 和骨代谢的具体情况仍不清楚。
从 Obuse 镇居民登记册中随机抽取年龄（50 多岁、60 多岁、70 多岁和 80 多岁）和性别后，建立了 8 个组。共纳入 411 名参与者（202 名男性和 209 名女性），以评估 BMD 和骨转换标志物。所有受试者均接受单次全脊柱侧位 X 线摄影检查，以确定是否存在 DISH。使用多元分析对 DISH 患者和非 DISH 患者的 BMD 和骨转换标志物进行分析，以探讨其与该疾病的相关性。
在我们的人群队列中，66 名（16.1%）参与者检测出 DISH。多元分析显示，腰椎和髋部 BMD 的增加与 DISH 显著相关（比值比分别为 7.47 和 22.8）。
本研究基于一般人群，明确了 DISH 患者与非 DISH 患者之间 BMD 和骨转换标志物的差异。多元分析显示，腰椎和髋部 BMD 的增加与 DISH 显著相关，而骨转换标志物无明显变化。
4 级。
