铜催化硼化树枝状大分子的预硼化反应：一种区域和立体选择性合成官能化 1,3-二烯的方法。
Copper-catalyzed protoboration of borylated dendralenes: a regio- and stereoselective access to functionalized 1,3-dienes.
机构信息
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
出版信息
Chem Commun (Camb). 2020 Oct 13;56(81):12230-12233. doi: 10.1039/d0cc04018e.
PMID:32926014
Abstract
A copper-catalyzed protoboration of borylated dendralenes is reported. The method employs an NHC-Cu catalyst and provides access to 1,4-addition products with excellent levels of chemo-, regio- and stereoselectivity. The resulting diene bis(boronates) are oxidized to the corresponding diene diols which are synthetically versatile building blocks.
摘要
本文报道了一种铜催化的硼化树枝状大分子的预硼化反应。该方法采用 NHC-Cu 催化剂，可高化学选择性、区域选择性和立体选择性地得到 1,4-加成产物。得到的二烯双（硼酸酯）被氧化为相应的二烯二醇，它们是具有合成多功能性的构建块。
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