Liu Sensheng, Liu Yangbin, Flaget Arthur, Zhang Cheng, Mazet Clément
Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland.
Org Lett. 2023 Sep 22;25(37):6897-6901. doi: 10.1021/acs.orglett.3c02627. Epub 2023 Sep 11.
A Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes is described. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates in consistently high yield, regioselectivity, and enantiomeric ratio. Preliminary investigations point to a complex mechanism.
本文描述了一种铜催化的2,3-二取代1,3-二烯的区域和对映选择性原硼化反应。该方法在温和条件下进行，适用于对称和不对称取代的二烯，能够以始终如一的高产率、区域选择性和对映体比例获得高烯丙基硼酸酯。初步研究表明其反应机理较为复杂。
Zotero 插件
