Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany.
Magn Reson Med. 2021 Feb;85(2):912-925. doi: 10.1002/mrm.28482. Epub 2020 Sep 14.
To test the feasibility of 3D phase-resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease, to compare 3D to 2D PREFUL, and to investigate the required temporal resolution to obtain stable 3D PREFUL measurement.
Sixteen participants underwent MRI using 2D and 3D PREFUL. Retrospectively, the spatial resolution of 3D PREFUL (4 × 4 × 4 mm ) was decreased to match the spatial resolution of 2D PREFUL (4 × 4 × 15 mm ), abbreviated as 3D . In addition to regional ventilation (RVent), flow-volume loops were computed and rated by a cross-correlation (CC). Ventilation defect percentage (VDP) maps were obtained. RVent, CC, VDP , and VDP were compared for systematic differences between 2D, 3D , and 3D PREFUL. Dividing the 3D PREFUL data into 4- (≈ 20 phases), 8- (≈ 40 phases), and 12-min (≈ 60 phases) acquisition pieces, the ventilation parameter maps, including the heterogeneity of ventilation time to peak, were tested regarding the required temporal resolution.
RVent, CC, VDP , and VDP presented significant correlations between 2D and 3D PREFUL (r = 0.64-0.94). CC and VDP of 2D and 3D PREFUL were significantly different (P < .0113). Comparing 3D and 3D PREFUL, all parameters were found to be statistically different (P < .0045).
3D PREFUL MRI depicts the whole lung volume and breathing cycle with superior image resolution and with likely more precision compared to 2D PREFUL. Furthermore, 3D PREFUL is more sensitive to detect regions of hypoventilation and ventilation heterogeneity compared to 3D PREFUL, which is important for early detection and improved monitoring of patients with chronic lung disease.
测试三维相位分辨功能肺（PREFUL）MRI 在健康志愿者和慢性肺部疾病患者中的可行性，比较三维和二维 PREFUL，并研究获得稳定三维 PREFUL 测量所需的时间分辨率。
16 名参与者接受了使用二维和三维 PREFUL 的 MRI 检查。回顾性地，将三维 PREFUL 的空间分辨率（4×4×4mm）降低到与二维 PREFUL 的空间分辨率（4×4×15mm）匹配，缩写为 3D。除了区域性通气（RVent），还计算并通过互相关（CC）对流量-容积环进行评分。获得通气缺陷百分比（VDP）图。比较 2D、3D 和 3D PREFUL 之间的 Rvent、CC、VDP 和 VDP 的系统差异。将 3D PREFUL 数据分为 4-（≈20 个相位）、8-（≈40 个相位）和 12 分钟（≈60 个相位）采集片段，测试通气参数图，包括到达峰值的通气时间异质性，以确定所需的时间分辨率。
RVent、CC、VDP 和 VDP 在 2D 和 3D PREFUL 之间呈现显著相关性（r=0.64-0.94）。2D 和 3D PREFUL 的 CC 和 VDP 有显著差异（P<.0113）。比较 3D 和 3D PREFUL，所有参数均存在统计学差异（P<.0045）。
与二维 PREFUL 相比，三维 PREFUL MRI 以更高的图像分辨率描绘整个肺容积和呼吸周期，并且可能更精确。此外，与三维 PREFUL 相比，三维 PREFUL 更能敏感地检测到通气不足和通气异质性的区域，这对于早期检测和改善慢性肺部疾病患者的监测非常重要。
