Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Mov Disord. 2020 Dec;35(12):2240-2249. doi: 10.1002/mds.28243. Epub 2020 Sep 14.
To investigate the role of motor cerebellar connectivity in future development of freezing of gait, because it is a complex network disorder in Parkinson's disease (PD).
We recruited 26 de novo patients with PD who experienced freezing of gait within 5 years from magnetic resonance imaging acquisition (vulnerable PD group), 61 patients with PD who had not experienced freezing of gait within 5 years (resistant PD group), and 27 healthy control subjects. We compared the resting state functional connectivity between the motor cerebellum and the whole brain between the groups. In addition, we evaluated the relationship between motor cerebellar connectivity and freezing of gait latency.
The vulnerable PD group had increased functional connectivity between the motor cerebellum and parieto-occipito-temporal association cortices compared with the control group or the resistant PD group. Connectivity between lobule VI and the right superior parietal lobule, right fusiform gyrus, and left inferior temporal gyrus; between lobule VIIb and the right superior parietal lobule, right hippocampus, and right middle temporal gyrus; and between lobule VIIIb and the bilateral fusiform gyri, right middle occipital gyrus, and bilateral parietal lobes was inversely proportional to freezing of gait latency. The freezing of gait latency-related cortical functional connectivity from the motor cerebellum was also significantly higher in the vulnerable PD group compared with the control group, as well as the resistant PD group.
The data suggest that the motor cerebellar functional connectivity with the posterior cortical areas play an important role in future development of freezing of gait in PD. © 2020 International Parkinson and Movement Disorder Society.
研究运动小脑连接在未来冻结步态发展中的作用，因为这是帕金森病（PD）中的一种复杂网络障碍。
我们招募了 26 名新诊断为 PD 的患者，他们在磁共振成像采集后 5 年内出现了冻结步态（易冻结步态 PD 组），61 名 PD 患者在 5 年内未出现冻结步态（不易冻结步态 PD 组），以及 27 名健康对照者。我们比较了三组之间运动小脑与全脑之间的静息状态功能连接。此外，我们还评估了运动小脑连接与冻结步态潜伏期之间的关系。
易冻结步态 PD 组与对照组或不易冻结步态 PD 组相比，运动小脑与顶枕颞叶联合皮质之间的功能连接增加。VI 小叶与右侧顶叶上回、右侧梭状回和左侧颞下回之间的连接；VIIb 小叶与右侧顶叶上回、右侧海马和右侧颞中回之间的连接；VIIIb 小叶与双侧梭状回、右侧中枕叶和双侧顶叶之间的连接与冻结步态潜伏期呈反比。易冻结步态 PD 组运动小脑与皮质相关的冻结步态潜伏期功能连接也明显高于对照组和不易冻结步态 PD 组。
这些数据表明，运动小脑与后皮质区的功能连接在 PD 冻结步态的未来发展中起着重要作用。© 2020 国际帕金森病和运动障碍学会。
