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BRCA 阳性女性生殖决策的综合回顾

Integrative Review of Reproductive Decision Making of Women Who Are BRCA Positive.

出版信息

J Obstet Gynecol Neonatal Nurs. 2020 Nov;49(6):525-536. doi: 10.1016/j.jogn.2020.07.006. Epub 2020 Sep 11.

Abstract

OBJECTIVE

To synthesize research findings about reproductive decision making among women who are BRCA positive.

DATA SOURCES

PubMed and CINAHL.

STUDY SELECTION

Articles published in English between 2000 and June 28, 2020, about the reproductive decision making of women with a confirmed BRCA1 or BRCA2 mutation.

DATA EXTRACTION

We extracted data about participants, study design, analysis, follow-up, and results. We used the modified Downs and Black checklist and Kennelly's qualitative data analysis to rate studies for quality and applicability by using.

DATA SYNTHESIS

We included five of 257 screened articles in our synthesis. The total sample size of the five studies was 1,468 women. The most prevalent factors related to reproductive decision making were the impending decisions regarding childbearing and family choices, including decisions about biological children, preventive surgery, preimplantation genetic diagnosis, and prenatal diagnosis to prevent further transmission of a BRCA mutation, and family planning.

CONCLUSION

A lack of knowledge exists about the reproductive decision-making processes of women who are BRCA positive. A better understanding of this process would provide nurses and other clinicians with the knowledge needed to support these women through their reproductive life choices.

摘要

目的

综合研究 BRCA 阳性女性的生殖决策。

资料来源

PubMed 和 CINAHL。

研究选择

发表于 2000 年至 2020 年 6 月 28 日期间的关于已确诊 BRCA1 或 BRCA2 突变的女性生殖决策的英文文章。

资料提取

我们提取了有关参与者、研究设计、分析、随访和结果的数据。我们使用改良的唐斯和布莱克清单和肯内利的定性数据分析,对研究的质量和适用性进行了评分。

资料综合

我们综合了 257 篇筛选文章中的 5 篇。五项研究的总样本量为 1468 名女性。与生殖决策最相关的因素包括即将做出的关于生育和家庭选择的决定,包括关于亲生子女、预防性手术、植入前基因诊断和产前诊断以防止 BRCA 突变进一步传播的决定,以及计划生育。

结论

对 BRCA 阳性女性的生殖决策过程缺乏了解。更好地了解这一过程将为护士和其他临床医生提供支持这些女性做出生殖选择所需的知识。

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