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斑秃专家共识(ACE)研究第二部分:关于斑秃诊断和实验室评估的国际专家意见结果

The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata.

作者信息

Meah Nekma, Wall Dmitri, York Katherine, Bhoyrul Bevin, Bokhari Laita, Asz-Sigall Daniel, Bergfeld Wilma F, Betz Regina C, Blume-Peytavi Ulrike, Callender Valerie, Chitreddy Vijaya, Combalia Andrea, Cotsarelis George, Craiglow Brittany, Donovan Jeff, Eisman Samantha, Farrant Paul, Green Jack, Grimalt Ramon, Harries Matthew, Hordinsky Maria, Irvine Alan D, Itami Satoshi, Jolliffe Victoria, King Brett, Lee Won-Soo, McMichael Amy, Messenger Andrew, Mirmirani Paradi, Olsen Elise, Orlow Seth J, Piraccini Bianca Maria, Rakowska Adriana, Reygagne Pascal, Roberts Janet L, Rudnicka Lidia, Shapiro Jerry, Sharma Pooja, Tosti Antonella, Vogt Annika, Wade Martin, Yip Leona, Zlotogorski Abraham, Sinclair Rodney D

机构信息

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Hair Restoration Blackrock, Ireland; National and International Skin Registry Solutions (NISR), Ireland.

出版信息

J Am Acad Dermatol. 2021 Jun;84(6):1594-1601. doi: 10.1016/j.jaad.2020.09.028. Epub 2020 Sep 12.

DOI:10.1016/j.jaad.2020.09.028
PMID:32926985
Abstract

BACKGROUND

We previously reported the Alopecia Areata Consensus of Experts study, which presented results of an international expert opinion on treatments for alopecia areata.

OBJECTIVE

To report the results of the Alopecia Areata Consensus of Experts international expert opinion on diagnosis and laboratory evaluation for alopecia areata.

METHODS

Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Consensus threshold was set at greater than or equal to 66%.

RESULTS

Of 148 questions, expert consensus was achieved in 82 (55%). Round 1 consensus was achieved in 10 of 148 questions (7%). Round 2 achieved consensus in 47 of 77 questions (61%). The final face-to-face achieved consensus in 25 of 32 questions (78%). Consensus was greatest for laboratory evaluation (12 of 14 questions [86%]), followed by diagnosis (11 of 14 questions [79%]) of alopecia areata. Overall, etiopathogenesis achieved the least category consensus (31 of 68 questions [46%]).

LIMITATIONS

The study had low representation from Africa, South America, and Asia.

CONCLUSION

There is expert consensus on aspects of epidemiology, etiopathogenesis, clinical features, diagnosis, laboratory evaluation, and prognostic indicators of alopecia areata. The study also highlights areas where future clinical research could be directed to address unresolved hypotheses in alopecia areata patient care.

摘要

背景

我们之前报道了斑秃专家共识研究,该研究展示了关于斑秃治疗的国际专家意见结果。

目的

报告斑秃专家共识关于斑秃诊断和实验室评估的国际专家意见结果。

方法

邀请来自5个大洲的50位毛发专家参与三轮德尔菲法流程。共识阈值设定为大于或等于66%。

结果

在148个问题中,82个(55%)达成了专家共识。第一轮在148个问题中的10个(7%)达成了共识。第二轮在77个问题中的47个(61%)达成了共识。最后的面对面会议在32个问题中的25个(78%)达成了共识。关于实验室评估(14个问题中的12个[86%])的共识最大,其次是斑秃的诊断(14个问题中的11个[79%])。总体而言,病因发病机制达成的类别共识最少(68个问题中的31个[46%])。

局限性

该研究在非洲、南美洲和亚洲的代表性较低。

结论

在斑秃的流行病学、病因发病机制、临床特征、诊断、实验室评估和预后指标方面存在专家共识。该研究还突出了未来临床研究可针对解决斑秃患者护理中未解决假设的领域。

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