Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Compr Psychiatry. 2020 Oct;102:152196. doi: 10.1016/j.comppsych.2020.152196. Epub 2020 Aug 12.
Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression.
Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay.
IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001).
The significance of the results is limited by the retrospective design and methodological aspects.
The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression.
单相抑郁症是一种常见且使人虚弱的疾病。近年来，免疫学解释方法变得越来越重要，在脑脊液（CSF）中可以特别好地研究这些方法。以前的研究发现白细胞介素（IL）-6 和 IL-8 水平发生了变化；然而，关于 IL-8 的研究结果部分是相互矛盾的。本研究的目的是研究单相抑郁症患者 CSF 中不同细胞因子和趋化因子（重点是 IL-8）的浓度。
参与者包括 40 名单相抑郁症患者和 39 名患有特发性颅内高压的心理健康对照组。使用磁珠多重免疫测定法测量 CSF 细胞因子水平。
抑郁组患者的 CSF 中 IL-8 水平明显高于对照组（平均值±标准差：38.44±6.26pg/ml 与 21.40±7.96pg/ml；p<0.001）。
结果的意义受到回顾性设计和方法学方面的限制。
本研究的主要发现是单相抑郁症患者 CSF 中 IL-8 浓度明显高于对照组。本研究中 CSF 中高 IL-8 水平的检测支持炎症过程可能在抑郁症患者亚组的病理生理学中起作用的观点。
