Méndez-García Lucía Angélica, Solleiro-Villavicencio Helena, Guartazaca-Guerrero Sebastián, Rodríguez-Morales Jahir, Carrillo-Ruiz José Damián
Laboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City 03100, Mexico.
Trop Med Infect Dis. 2023 May 25;8(6):290. doi: 10.3390/tropicalmed8060290.
Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain-blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the dysregulation of total cell counts. In this article, based on the compilation of studies reported by our working group regarding COVID-19 and neurological diseases, we propose that the inflammation observed in the central nervous system, through a CSF analysis, could be conditioned by neurological disease(s) and enhanced by COVID-19. Therefore, it is necessary to determine the cytokine profile in different neurological disorders to propose adequate treatments and avoid severe forms of the disease in these patients.
神经炎症在神经疾病的发生和发展过程中至关重要。潜在的促炎细胞因子表达，再加上神经病理学中的其他机制，如氧化应激、血脑屏障损伤和内皮功能障碍，可能会导致感染严重 COVID-19 的易感性增加。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）和其他人类冠状病毒（H-CoVs）的生理病理学尚未完全明确；然而，它们都与免疫系统的过度反应有关，特别是细胞因子产生加剧和全血细胞计数失调。在本文中，基于我们工作组报告的关于 COVID-19 和神经疾病的研究汇编，我们提出，通过脑脊液分析在中枢神经系统中观察到的炎症可能受神经疾病影响，并因 COVID-19 而加剧。因此，有必要确定不同神经疾病中的细胞因子谱，以提出适当的治疗方案，并避免这些患者出现严重的疾病形式。
