Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8849, Dallas, TX 75390-8849, United States of America.
Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8830, United States of America.
J Neuroimmunol. 2020 Nov 15;348:577386. doi: 10.1016/j.jneuroim.2020.577386. Epub 2020 Sep 8.
Galectin-3 (Gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. The present study examined whether serum Gal3 levels predict hippocampal volume in a multi-ethnic, community-based sample. Results of a multiple linear regression (controlling for depression, serum creatinine level, age, BMI, total brain volume, MoCA score, sex, ethnicity, smoking status, history of diabetes) showed that Gal3 levels significantly predicted left (p = .027) but not right hippocampal volume. The relationship was stronger in men than women. Findings suggest this novel inflammatory biomarker is associated with human hippocampal volume.
半乳糖凝集素-3（Gal3）由小胶质细胞表达，具有黏附、激活巨噬细胞和成纤维细胞的功能，并在海马体中介导炎症反应。本研究在一个多民族的社区样本中，检测了血清 Gal3 水平是否可以预测海马体体积。多元线性回归的结果（控制抑郁、血清肌酐水平、年龄、BMI、总脑体积、MoCA 评分、性别、种族、吸烟状况、糖尿病史）表明，Gal3 水平显著预测左侧（p =.027）但不预测右侧海马体体积。这种关系在男性中比女性更强。这些发现表明，这种新型炎症生物标志物与人类海马体体积有关。
