Department of Neurology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, China
Central Laboratory, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, China
Curr Neuropharmacol. 2020;18(12):1213-1226. doi: 10.2174/1570159X18666200914162013.
Ischemic stroke is one of the main causes of mortality and disability worldwide. However, efficient therapeutic strategies are still lacking. Stem/progenitor cell-based therapy, with its vigorous advantages, has emerged as a promising tool for the treatment of ischemic stroke. The mechanisms involve new neural cells and neuronal circuitry formation, antioxidation, inflammation alleviation, angiogenesis, and neurogenesis promotion. In the past decades, in-depth studies have suggested that cell therapy could promote vascular stabilization and decrease blood-brain barrier (BBB) leakage after ischemic stroke. However, the effects and underlying mechanisms on BBB integrity induced by the engrafted cells in ischemic stroke have not been reviewed yet. Herein, we will update the progress in research on the effects of cell therapy on BBB integrity after ischemic stroke and review the underlying mechanisms. First, we will present an overview of BBB dysfunction under the ischemic condition and cells engraftment for ischemic treatment. Then, we will summarize and discuss the current knowledge about the effects and underlying mechanisms of cell therapy on BBB integrity after ischemic stroke. In particular, we will review the most recent studies in regard to the relationship between cell therapy and BBB in tissue plasminogen activator (t-PA)-mediated therapy and diabetic stroke.
缺血性脑卒中是全球范围内导致死亡和残疾的主要原因之一。然而，目前仍缺乏有效的治疗策略。基于干细胞/祖细胞的治疗方法具有多种优势，已成为治疗缺血性脑卒中的一种有前途的工具。其作用机制涉及新的神经细胞和神经元回路形成、抗氧化、减轻炎症、血管生成和促进神经发生。在过去的几十年中，深入的研究表明，细胞治疗可以促进缺血性脑卒中后血管的稳定和血脑屏障（BBB）的渗漏减少。然而，移植细胞对缺血性脑卒中后 BBB 完整性的影响及其潜在机制尚未得到综述。本文将更新细胞治疗对缺血性脑卒中后 BBB 完整性的影响及其潜在机制的研究进展。首先，我们将介绍缺血条件下 BBB 功能障碍和用于缺血治疗的细胞移植的概述。然后，我们将总结和讨论细胞治疗对缺血性脑卒中后 BBB 完整性的影响及其潜在机制的现有知识。特别是，我们将回顾关于细胞治疗与组织型纤溶酶原激活剂（t-PA）介导的治疗和糖尿病性脑卒中的 BBB 之间关系的最新研究。
