Department of Pharmacy, Pranveer Singh Institute Of Technology, Kanpur - Agra - Delhi National Highway - 2 , Bhauti - Kanpur - 209305, India.
Curr Diabetes Rev. 2021;17(3):247-258. doi: 10.2174/1573399816666200914141558.
Chronic hyperglycemia and related complications involving peripheral nerves in diabetes are one of the most severe microvascular complications with an average prevalence of 50-60%. Diabetic neuropathy is among the vascular disorders of diabetes, the most debilitating and crippled, lethal condition impacting patients's quality of life.
In the present review article, several hypotheses associated with the pathogenesis of Diabetic Peripheral Neuropathy (DPN) have been introduced, among them metabolic pathways associated with polyol pathway, oxidative stress, production of reactive oxygen species (ROS) amplified under chronic hyperglycemic conditions and activation of transcription factor Nuclear factor-κB (NF- κB). The review article also possesses pathogenetic and pharmacologic treatments along with others, including acupressure, lidocaine, and capsaicin for DPN.
It may be concluded that we can combat the pathogenesis of DPN with different suggested treatments.
糖尿病患者的慢性高血糖及相关并发症会累及外周神经，这是最严重的微血管并发症之一，其平均患病率为 50-60%。糖尿病神经病变是糖尿病血管病变中最具致残性和致瘫性、最致命的一种疾病，会影响患者的生活质量。
在本综述文章中，我们介绍了几种与糖尿病周围神经病变（DPN）发病机制相关的假说，其中包括与多元醇途径、氧化应激、慢性高血糖条件下活性氧（ROS）产生以及转录因子核因子-κB（NF-κB）激活相关的代谢途径。该综述文章还介绍了 DPN 的发病机制和药物治疗方法，包括穴位按压、利多卡因和辣椒素等。
我们可以用不同的治疗方法来对抗 DPN 的发病机制。
