• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ANGPTL4 过表达抑制肿瘤细胞黏附和迁移，并预测三阴性乳腺癌的预后良好。

ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer.

机构信息

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People's Republic of China.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, Guangdong, 510060, People's Republic of China.

出版信息

BMC Cancer. 2020 Sep 14;20(1):878. doi: 10.1186/s12885-020-07343-w.

DOI:10.1186/s12885-020-07343-w
PMID:32928141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7489026/
Abstract

BACKGROUND

Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with TNBC could help guide treatment. Extensive evidence demonstrates that angiopoietin-like 4 (ANGPTL4) is involved in the regulation of cancer growth, metastasis and angiogenesis. Therefore, its role in TNBC is of interest.

METHODS

We tested the ANGPTL4 expression level in tumor tissues by immunohistochemistry (IHC) and detected its association with the clinical features of TNBC patients. Next, the effects and mechanisms of ANGPTL4 on TNBC cell migration and adhesion were investigated.

RESULTS

We found that ANGPTL4 overexpression was associated with favorable outcomes in TNBC patients. ANGPTL4 upregulation inhibited cell adhesion, migration and invasion in vitro. Further analyses demonstrated that the possible mechanism might involve suppression of TNBC progression by interacting with extracellular matrix-related genes.

CONCLUSIONS

The present findings demonstrated that enhancement of ANGPTL4 expression might inversely correlate with TNBC progression. ANGPTL4 is a promising marker of TNBC and should be evaluated in further studies.

TRIAL REGISTRATION

Retrospectively registered.

摘要

背景

三阴性乳腺癌（TNBC）患者的临床预后相对较差。一种能预测 TNBC 患者预后的标志物，有助于指导治疗。大量证据表明，血管生成素样蛋白 4（ANGPTL4）参与了癌症生长、转移和血管生成的调控。因此，其在 TNBC 中的作用引起了关注。

方法

我们通过免疫组织化学（IHC）检测肿瘤组织中 ANGPTL4 的表达水平，并检测其与 TNBC 患者临床特征的相关性。接下来，我们研究了 ANGPTL4 对 TNBC 细胞迁移和黏附的影响及其作用机制。

结果

我们发现 ANGPTL4 过表达与 TNBC 患者的良好预后相关。ANGPTL4 的上调抑制了体外细胞黏附、迁移和侵袭。进一步的分析表明，其可能的机制可能涉及通过与细胞外基质相关基因相互作用抑制 TNBC 的进展。

结论

本研究结果表明，ANGPTL4 表达的增强可能与 TNBC 的进展呈负相关。ANGPTL4 是 TNBC 有前途的标志物，值得在进一步的研究中进行评估。

试验注册

回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/27e3bcc97b43/12885_2020_7343_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/ddbddcc62681/12885_2020_7343_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/dd7deaa16b6d/12885_2020_7343_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/27e3bcc97b43/12885_2020_7343_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/ddbddcc62681/12885_2020_7343_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/dd7deaa16b6d/12885_2020_7343_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79e/7489026/27e3bcc97b43/12885_2020_7343_Fig3_HTML.jpg

相似文献

1
ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer.ANGPTL4 过表达抑制肿瘤细胞黏附和迁移，并预测三阴性乳腺癌的预后良好。
BMC Cancer. 2020 Sep 14;20(1):878. doi: 10.1186/s12885-020-07343-w.
2
USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.USP2促进三阴性乳腺癌细胞系中的细胞迁移和侵袭。
Tumour Biol. 2015 Jul;36(7):5415-23. doi: 10.1007/s13277-015-3207-7. Epub 2015 Feb 17.
3
MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells.MEK依赖的白细胞介素-8诱导调节三阴性乳腺癌细胞的侵袭性。
Tumour Biol. 2016 Apr;37(4):4991-9. doi: 10.1007/s13277-015-4345-7. Epub 2015 Nov 4.
4
MiR-92b inhibited cells EMT by targeting Gabra3 and predicted prognosis of triple negative breast cancer patients.miR-92b 通过靶向 Gabra3 抑制细胞 EMT，预测三阴性乳腺癌患者的预后。
Eur Rev Med Pharmacol Sci. 2019 Dec;23(23):10433-10442. doi: 10.26355/eurrev_201912_19682.
5
RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.RNA 结合蛋白 MSI2 异构体在三阴性乳腺癌进展中的表达和调控。
J Exp Clin Cancer Res. 2020 May 24;39(1):92. doi: 10.1186/s13046-020-01587-x.
6
miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer.miR-17-5p 通过靶向 ETV1 抑制三阴性乳腺癌细胞增殖和侵袭。
BMC Cancer. 2017 Nov 10;17(1):745. doi: 10.1186/s12885-017-3674-x.
7
Diaphanous-related formin-3 overexpression inhibits the migration and invasion of triple-negative breast cancer by inhibiting RhoA-GTP expression.卷曲相关形态发生蛋白 3 过表达通过抑制 RhoA-GTP 表达抑制三阴性乳腺癌的迁移和侵袭。
Biomed Pharmacother. 2017 Oct;94:439-445. doi: 10.1016/j.biopha.2017.07.119. Epub 2017 Aug 2.
8
LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis.长链非编码 RNA FAM83H-AS1 通过调控 miR-136-5p/metadherin 轴促进三阴性乳腺癌的进展。
Aging (Albany NY). 2020 Feb 17;12(4):3594-3616. doi: 10.18632/aging.102832.
9
MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1.微小RNA-211-5p通过直接靶向SETBP1抑制三阴性乳腺癌中的肿瘤细胞增殖、侵袭、迁移和转移。
Br J Cancer. 2017 Jun 27;117(1):78-88. doi: 10.1038/bjc.2017.150. Epub 2017 Jun 1.
10
Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer.姜黄素通过调节伸长因子 2 激酶（eEF-2K）信号轴抑制三阴性乳腺癌细胞增殖、迁移和侵袭。
Breast Cancer Res Treat. 2018 Oct;171(3):593-605. doi: 10.1007/s10549-018-4847-2. Epub 2018 Jul 3.

引用本文的文献

1
ANGPTL4: A Comprehensive Review of 25 Years of Research.血管生成素样蛋白4：25年研究综述
Cancers (Basel). 2025 Jul 16;17(14):2364. doi: 10.3390/cancers17142364.
2
ANGPTL4 suppresses progression and improves cisplatin sensitivity in cervical cancer.血管生成素样蛋白4抑制宫颈癌进展并提高顺铂敏感性。
Sci Rep. 2025 Apr 23;15(1):14217. doi: 10.1038/s41598-025-99136-z.
3
The role of ANGPTL4 in cancer: A meta-analysis of observational studies and multi-omics investigation.血管生成素样蛋白4在癌症中的作用：观察性研究的荟萃分析和多组学调查

本文引用的文献

1
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4.肥胖相关炎症通过血管生成素样蛋白 4 促进血管生成和乳腺癌。
Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5.
2
Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment.肿瘤组织中双重作用信号介质 ANGPTL4 的表观遗传沉默及其在尿路上皮癌微环境中的过表达。
Oncogene. 2018 Feb 1;37(5):673-686. doi: 10.1038/onc.2017.375. Epub 2017 Oct 16.
3
Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.
PLoS One. 2025 Apr 15;20(4):e0320343. doi: 10.1371/journal.pone.0320343. eCollection 2025.
4
Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis.小鼠胰腺癌早期成纤维细胞中的基因表达动态
iScience. 2024 Dec 10;28(1):111572. doi: 10.1016/j.isci.2024.111572. eCollection 2025 Jan 17.
5
Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis.艰难梭菌来源的膜泡通过PPARγ/RXRα/ANGPTL4轴抑制滋养层细胞运动，从而促进胎儿生长受限。
NPJ Biofilms Microbiomes. 2024 Dec 31;10(1):158. doi: 10.1038/s41522-024-00630-5.
6
Emerging roles of angiopoietin‑like 4 in human tumors (Review).血管生成素样4在人类肿瘤中的新作用（综述）
Int J Oncol. 2025 Feb;66(2). doi: 10.3892/ijo.2024.5715. Epub 2024 Dec 20.
7
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers.非吸烟者中非小细胞肺癌的个性化遗传易感性特征
Cancers (Basel). 2024 Aug 20;16(16):2887. doi: 10.3390/cancers16162887.
8
ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase.ANGPTL4 通过抑制溶酶体酸性脂肪酶抑制透明细胞肾细胞癌。
Cancer Res Commun. 2024 Aug 1;4(8):2242-2254. doi: 10.1158/2767-9764.CRC-24-0016.
9
Investigating the Effects of Overexpression on Colorectal Cancer Cell Migration Oncolytic Virus Type 1 (oHSV-1).研究1型溶瘤病毒（oHSV-1）过表达对大肠癌细胞迁移的影响。
Avicenna J Med Biotechnol. 2024 Apr-Jun;16(2):120-129. doi: 10.18502/ajmb.v16i2.14863.
10
Transforming growth factor-induced gene TGFBI is correlated with the prognosis and immune infiltrations of breast cancer.转化生长因子诱导基因 TGFBI 与乳腺癌的预后和免疫浸润相关。
World J Surg Oncol. 2024 Jan 20;22(1):22. doi: 10.1186/s12957-024-03301-z.
缺氧诱导的ANGPTL4在胃癌中的表达调控及其临床意义
Oncol Lett. 2016 Feb;11(2):1026-1034. doi: 10.3892/ol.2015.4011. Epub 2015 Dec 8.
4
Gene expression in "young adult type" breast cancer: a retrospective analysis.“青年型”乳腺癌中的基因表达：一项回顾性分析。
Oncotarget. 2015 May 30;6(15):13688-702. doi: 10.18632/oncotarget.4051.
5
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.
6
Identification of genomic signatures in circulating tumor cells from breast cancer.从乳腺癌循环肿瘤细胞中鉴定基因组特征。
Int J Cancer. 2015 Jul 15;137(2):332-44. doi: 10.1002/ijc.29399. Epub 2015 Jan 12.
7
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.全球癌症发病与死亡：GLOBOCAN 2012 数据源、方法与主要模式。
Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9.
8
Emerging roles of angiopoietin-like 4 in human cancer.血管生成素样蛋白 4 在人类癌症中的新作用。
Mol Cancer Res. 2012 Jun;10(6):677-88. doi: 10.1158/1541-7786.MCR-11-0519. Epub 2012 Jun 1.
9
ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression.前列腺素 E2 在缺氧条件下诱导 ANGPTL4 的表达促进结直肠癌的进展。
Cancer Res. 2011 Nov 15;71(22):7010-20. doi: 10.1158/0008-5472.CAN-11-1262. Epub 2011 Sep 21.
10
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.缺氧乳腺癌细胞通过 HIF-1 依赖性表达血管生成素样蛋白 4 和 L1CAM 来介导血管向肺部转移。
Oncogene. 2012 Apr 5;31(14):1757-70. doi: 10.1038/onc.2011.365. Epub 2011 Aug 22.