将双氯芬酸钠重新用作辐射防护剂：一项针对人类外周血淋巴细胞的细胞遗传学研究。
Repurposing sodium diclofenac as a radiation countermeasure agent: A cytogenetic study in human peripheral blood lymphocytes.
作者信息
Alok Amit, Agrawala Paban K
机构信息
Division of Radiation Biodosimetry, Institute of Nuclear Medicine & Allied Sciences, Timarpur, Delhi, 110054, India.
Radiation Genetics & Epigenetics, Institute of Nuclear Medicine & Allied Sciences, Timarpur, Brig S K Mazumdar Marg, Delhi, 110054, India.
出版信息
Mutat Res Genet Toxicol Environ Mutagen. 2020 Aug-Sep;856-857:503220. doi: 10.1016/j.mrgentox.2020.503220. Epub 2020 Jul 4.
We assessed the radioprotective and mitigative actions of sodium diclofenac, a non-steroidal anti-inflammatory drug using cultured human peripheral blood as a model. Both pre- and post-irradiation treatments with the drug reduced gamma radiation-induced formation of dicentric chromosome, cytochalasin-blocked micronuclei and γ-H2AX foci in human peripheral blood lymphocytes. This work supports the concept that sodium diclofenac may be a useful radiation countermeasure agent.
我们以培养的人类外周血为模型，评估了非甾体抗炎药双氯芬酸钠的辐射防护和缓解作用。该药物的照射前和照射后处理均减少了γ辐射诱导的人类外周血淋巴细胞中双着丝粒染色体、细胞松弛素阻断微核和γ-H2AX病灶的形成。这项工作支持了双氯芬酸钠可能是一种有用的辐射对策剂的概念。
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