Hippo 信号通路在胚胎发生和发育中的作用。
Hippo Signaling in Embryogenesis and Development.
机构信息
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Trends Biochem Sci. 2021 Jan;46(1):51-63. doi: 10.1016/j.tibs.2020.08.008. Epub 2020 Sep 11.
Abstract
Hippo pathway components are structurally and functionally conserved and are notable for their role in controlling organ size. More diverse functions of the Hippo pathway have been recognized, including development, tissue homeostasis, wound healing and regeneration, immunity, and tumorigenesis. During embryogenesis, different signaling pathways are repeatedly and cooperatively activated, leading to differential gene expression in specific developmental contexts. In this article, we present an overview on the regulation and function of the Hippo pathway in mammalian early development. We introduce the Hippo pathway components and major upstream signals that act through this pathway to influence embryogenesis. We also discuss the roles of Hippo pathway in tissue specification and organ development during organogenesis.
摘要
Hippo 通路组件在结构和功能上是保守的，其在控制器官大小方面的作用尤为显著。人们已经认识到 Hippo 通路具有更多样的功能，包括发育、组织稳态、创伤愈合和再生、免疫和肿瘤发生。在胚胎发生过程中，不同的信号通路会被反复协同激活，导致特定发育背景下的差异基因表达。在本文中，我们概述了 Hippo 通路在哺乳动物早期发育中的调控和功能。我们介绍了 Hippo 通路的组成部分以及主要的上游信号，这些信号通过该通路发挥作用，影响胚胎发生。我们还讨论了 Hippo 通路在器官发生过程中组织特化和器官发育中的作用。
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