Department of Biochemistry, Chungnam National University, Daejeon 34134, Korea.
Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141; Department of Functional Genomics, Korea University of Science & Technology (UST), Daejeon 34113, Korea.
BMB Rep. 2023 Aug;56(8):417-425. doi: 10.5483/BMBRep.2023-0094.
In various organisms, the Hippo signaling pathway has been identified as a master regulator of organ size determination and tissue homeostasis. The Hippo signaling coordinates embryonic development, tissue regeneration and differentiation, through regulating cell proliferation and survival. The YAP and TAZ (YAP/TAZ) act as core transducers of the Hippo pathway, and they are tightly and exquisitely regulated in response to various intrinsic and extrinsic stimuli. Abnormal regulation or genetic variation of the Hippo pathway causes a wide range of human diseases, including cancer. Recent studies have revealed that Hippo signaling plays a pivotal role in the immune system and cancer immunity. Due to pathophysiological importance, the emerging role of Hippo signaling in blood cell differentiation, known as hematopoiesis, is receiving much attention. A number of elegant studies using a genetically engineered mouse (GEM) model have shed light on the mechanistic and physiological insights into the Hippo pathway in the regulation of hematopoiesis. Here, we briefly review the function of Hippo signaling in the regulation of hematopoiesis and immune cell differentiation. [BMB Reports 2023; 56(8): 417-425].
在各种生物体中，Hippo 信号通路已被确定为器官大小决定和组织平衡的主要调节剂。Hippo 信号通过调节细胞增殖和存活，协调胚胎发育、组织再生和分化。YAP 和 TAZ（YAP/TAZ）作为 Hippo 通路的核心转导子，它们在响应各种内在和外在刺激时受到紧密而精细的调节。Hippo 通路的异常调节或遗传变异导致广泛的人类疾病，包括癌症。最近的研究表明，Hippo 信号在免疫系统和癌症免疫中起着关键作用。由于其病理生理学的重要性，Hippo 信号在血细胞分化（即造血）中的新兴作用引起了广泛关注。使用基因工程小鼠（GEM）模型的一系列精巧研究揭示了 Hippo 通路在调节造血中的机制和生理见解。在这里，我们简要回顾了 Hippo 信号在造血和免疫细胞分化中的调节作用。[BMB 报告 2023；56(8):417-425]。
