阻断 CTGF 介导的胰腺癌肿瘤-基质相互作用。
Blocking CTGF-Mediated Tumor-Stroma Interplay in Pancreatic Cancer.
机构信息
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
出版信息
Trends Mol Med. 2020 Dec;26(12):1064-1067. doi: 10.1016/j.molmed.2020.08.005. Epub 2020 Sep 11.
As the major feature of pancreatic ductal adenocarcinoma (PDAC), desmoplastic stroma poses a significant obstacle for treatment. Recent studies revealed that connective tissue growth factor (CTGF) aggravates the fibrotic environment and drives cancer initiation and progression, thus suggesting CTGF as a novel target for PDAC treatment.
作为胰腺导管腺癌 (PDAC) 的主要特征，纤维性基质构成了治疗的重大障碍。最近的研究表明，结缔组织生长因子 (CTGF) 加剧了纤维化环境，并驱动癌症的发生和进展，因此 CTGF 被认为是 PDAC 治疗的一个新靶点。
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