通过阻断癌症相关成纤维细胞上的纤连蛋白结合整合素来靶向胰腺癌干细胞特性
Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts.
作者信息
Wu Chengsheng, Von Schalscha Tami, Sansanwal Diva, Qian Chen, Jiang Qinlin, Shepard Ryan M, Wettersten Hiromi I, McCormack Stephen J, Weis Sara M, Cheresh David A
机构信息
Department of Pathology, Moores Cancer Center, Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California.
Alpha Beta Therapeutics, Inc., Claremont, California.
出版信息
Cancer Res Commun. 2025 Jan 1;5(1):195-208. doi: 10.1158/2767-9764.CRC-24-0491.
Abstract
Simultaneous targeting of two integrins that function as receptors for FN, a protumor ECM protein, can prevent fibroblasts from supporting the malignant behavior of pancreatic cancer cells.
摘要
同时靶向两种作为肿瘤细胞外基质蛋白纤连蛋白（FN）受体的整合素，可阻止成纤维细胞支持胰腺癌细胞的恶性行为。
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