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通过阻断癌症相关成纤维细胞上的纤连蛋白结合整合素来靶向胰腺癌干细胞特性

Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts.

作者信息

Wu Chengsheng, Von Schalscha Tami, Sansanwal Diva, Qian Chen, Jiang Qinlin, Shepard Ryan M, Wettersten Hiromi I, McCormack Stephen J, Weis Sara M, Cheresh David A

机构信息

Department of Pathology, Moores Cancer Center, Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California.

Alpha Beta Therapeutics, Inc., Claremont, California.

出版信息

Cancer Res Commun. 2025 Jan 1;5(1):195-208. doi: 10.1158/2767-9764.CRC-24-0491.

DOI:10.1158/2767-9764.CRC-24-0491
PMID:39785683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11783622/
Abstract

Simultaneous targeting of two integrins that function as receptors for FN, a protumor ECM protein, can prevent fibroblasts from supporting the malignant behavior of pancreatic cancer cells.

摘要

同时靶向两种作为肿瘤细胞外基质蛋白纤连蛋白（FN）受体的整合素，可阻止成纤维细胞支持胰腺癌细胞的恶性行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/b1e11ae72a83/crc-24-0491_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/f5a90fab6b6c/crc-24-0491_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/59e4d65e00a8/crc-24-0491_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/c563485ea5ab/crc-24-0491_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/fe221b8166ac/crc-24-0491_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/c028a83c86ee/crc-24-0491_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/b2c1e11393a2/crc-24-0491_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/b1e11ae72a83/crc-24-0491_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/f5a90fab6b6c/crc-24-0491_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/59e4d65e00a8/crc-24-0491_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/c563485ea5ab/crc-24-0491_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/fe221b8166ac/crc-24-0491_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/c028a83c86ee/crc-24-0491_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/b2c1e11393a2/crc-24-0491_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/11783622/b1e11ae72a83/crc-24-0491_f7.jpg

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本文引用的文献

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J Cell Sci. 2023 Oct 15;136(20). doi: 10.1242/jcs.261483. Epub 2023 Oct 23.
2
Tumor-initiating cells establish a niche to overcome isolation stress.肿瘤起始细胞建立小生境以克服隔离应激。
Trends Cell Biol. 2024 May;34(5):380-387. doi: 10.1016/j.tcb.2023.08.001. Epub 2023 Aug 26.
3
Cancer-associated fibroblasts: from basic science to anticancer therapy.
癌相关成纤维细胞：从基础科学到抗癌治疗。
Exp Mol Med. 2023 Jul;55(7):1322-1332. doi: 10.1038/s12276-023-01013-0. Epub 2023 Jul 3.
4
Fibronectin-targeted FUD and PEGylated FUD peptides for fibrotic diseases.靶向纤维连接蛋白的 FUD 和聚乙二醇化的 FUD 肽用于纤维化疾病。
J Control Release. 2023 Aug;360:69-81. doi: 10.1016/j.jconrel.2023.06.008. Epub 2023 Jun 22.
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Cancer-associated fibroblasts: challenges and opportunities.癌症相关成纤维细胞：挑战与机遇
Oncotarget. 2023 Mar 21;14:211-214. doi: 10.18632/oncotarget.28385.
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Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions.靶向癌症相关成纤维细胞：挑战、机遇与未来方向。
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