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一名病情危急的5周大婴儿的非典型新冠肺炎病例。

Atypical case of COVID-19 in a critically unwell 5-week old infant.

作者信息

Namasivayam Abirami, Soe Than, Palman Jason

机构信息

Paediatrics, Princess Alexandra Hospital NHS Trust, Harlow, UK

Paediatrics, Princess Alexandra Hospital NHS Trust, Harlow, UK.

出版信息

BMJ Case Rep. 2020 Sep 14;13(9):e237142. doi: 10.1136/bcr-2020-237142.

Abstract

The effect of COVID-19 by SARS-CoV-2 on the paediatric population remains an evolving mystery. Early reports from China stated that children seem to be unharmed by its dangerous effects, yet more recently there has been evidence of a systemic inflammatory response in a small number of children who are affected. We discuss a 5-week-old male infant who presented atypically with severe COVID-19 infection. To our knowledge, he is the youngest reported case in the UK to require mechanical ventilation and intensive care treatment as a direct result of COVID-19 following horizontal transmission. This case has generated several learning points with regard to atypical presentations of COVID-19 and identifying a potential cohort of 'at risk' infants. We also highlight a number of new challenges that have arisen for paediatricians and anaesthetists providing airway management for infants with SARS-CoV-2.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)对儿童群体的影响仍是一个不断发展的谜团。来自中国的早期报告称,儿童似乎未受其危险影响,但最近有证据表明,少数受感染儿童出现了全身炎症反应。我们讨论了一名5周大的男婴,他以非典型表现出现严重的COVID-19感染。据我们所知,他是英国报告的因水平传播感染COVID-19而需要机械通气和重症监护治疗的最年幼病例。该病例在COVID-19的非典型表现以及确定潜在的“高危”婴儿群体方面产生了几个经验教训。我们还强调了为感染SARS-CoV-2的婴儿提供气道管理的儿科医生和麻醉师所面临的一些新挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a3/7490956/d3e911ab3f92/bcr-2020-237142f01.jpg

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本文引用的文献

1
COVID-19 in Children: An Epidemiology Study from China.儿童新冠病毒感染:一项来自中国的流行病学研究。
J Allergy Clin Immunol Pract. 2020 Jun;8(6):2118-2120. doi: 10.1016/j.jaip.2020.04.024. Epub 2020 Apr 21.
2
Hyperinflammatory shock in children during COVID-19 pandemic.新冠疫情期间儿童的高炎症性休克
Lancet. 2020 May 23;395(10237):1607-1608. doi: 10.1016/S0140-6736(20)31094-1. Epub 2020 May 7.
3
COVID-19 virus and children: What do we know?新冠病毒与儿童:我们了解什么?
Arch Pediatr. 2020 Apr;27(3):117-118. doi: 10.1016/j.arcped.2020.03.001.

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