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药物通过抑制 TLR4/NF-κB 通路治疗炎症性肠病（IBD）的作用。

The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF-kappaB pathway.

机构信息

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Phytother Res. 2021 Feb;35(2):835-845. doi: 10.1002/ptr.6866. Epub 2020 Sep 14.

DOI:10.1002/ptr.6866
PMID:32929778
Abstract

Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll-like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines.

摘要

炎症性肠病（IBD）是一种终生且反复发作的胃肠道疾病，困扰着世界上许多人。目前越来越多的证据表明，免疫系统功能障碍，特别是 Toll 样受体 4（TLR4）信号通路功能障碍，在 IBD 的发病机制中起着关键作用。TLR4 信号通路既参与 IBD 的发病机制，也参与 IBD 的治疗效果。有一些药物和草药，它们通过调节 TLR4 信号通路在治疗 IBD 中的作用已被涉及。本文的目的是总结这些药物和草药。

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