Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaakob Latif, Kuala Lumpur, Malaysia.
Department of Obstetrics and Gynaecology, Hospital Tengku Ampuan Rahimah, Jalan Langat, Klang Selangor, Malaysia.
Asia Pac Psychiatry. 2022 Mar;14(1):e12416. doi: 10.1111/appy.12416. Epub 2020 Sep 14.
Hyperemesis Gravidarum (HG) is a severe form of vomiting that occurs among pregnant mothers. Due to the nature of HG, pregnant mothers may feel fatigued and burdened by it and questions have been raised about the emergence of psychiatric illness during this period of vulnerability.
A comparative cross-sectional study using Hospital Anxiety and Depression Scale (HADS), M.I.N.I (MINI International Neuropsychiatric Interview) and ENRICH- EMS (Evaluation and Nurturing Relationship Issues, Communication and Happiness - Marital Satisfaction Scale) were performed in a group of 112 pregnant women.
There were no differences in the prevalence rate of any anxiety disorder among the patient with HG vs comparative group (9% vs 3%, P > 0.05) and depressive disorder in women with HG vs comparative group (16% vs 8%, P > 0.05) respectively. There were associations between HG and gravida, past history of miscarriage, and gestational diabetes (P < 0.05). After adjustment, only past history of gestational diabetes was associated with HG as a protective factor (AOR 0.034 95% CI 0.002-0.181; P = 0.0014). We found that women in the HG group tended to score statistically significantly higher than the comparison group for depressive symptoms in the HADS Depression subscale (P = 0.041).
We found no convincing association between HG and anxiety disorder, depressive disorder, and marital satisfaction, but women with HG statistically significantly reported more depressive symptoms than women who were not diagnosed with HG. Psychiatric evaluation should be considered for women with HG.
妊娠剧吐(HG)是孕妇中发生的一种严重呕吐形式。由于 HG 的性质,孕妇可能会感到疲惫不堪,并对此感到困扰,因此有人提出在这段脆弱时期是否会出现精神疾病。
采用医院焦虑抑郁量表(HADS)、MINI(MINI 国际神经精神病学访谈)和 ENRICH-EMS(评估和培养关系问题、沟通和幸福-婚姻满意度量表)对 112 名孕妇进行了比较性横断面研究。
HG 组与对照组相比,任何焦虑障碍的患病率均无差异(9%比 3%,P>0.05),HG 组与对照组相比,抑郁障碍的患病率也无差异(16%比 8%,P>0.05)。HG 与孕次、既往流产史和妊娠期糖尿病有关(P<0.05)。调整后,只有既往妊娠期糖尿病史与 HG 呈保护因素相关(AOR 0.034 95%CI 0.002-0.181;P=0.0014)。我们发现,HG 组的女性在 HADS 抑郁量表中,抑郁症状的评分明显高于对照组(P=0.041)。
我们没有发现 HG 与焦虑障碍、抑郁障碍和婚姻满意度之间有令人信服的关联,但与未被诊断为 HG 的女性相比,HG 女性的抑郁症状报告明显更多。应对 HG 女性进行精神评估。