Department of Psychiatry, University of Konya, Meram Faculty of Medicine, Konya, Turkey.
Gen Hosp Psychiatry. 2012 Jul-Aug;34(4):398-402. doi: 10.1016/j.genhosppsych.2012.03.021. Epub 2012 May 2.
Intractable nausea and vomiting, known as hyperemesis gravidarum (HG), are relatively common medical problems among pregnant women. Although there are some studies based on psychiatric symptom scales, the relationship between HG and psychiatric disorders, particularly anxiety and personality disorders, is unclear. In this study, we aimed to investigate whether there is a difference among women with and without HG with respect to frequency of mood, anxiety and personality disorders.
The study sample was composed of 52 patients with HG and 90 control pregnant women. Mood and anxiety disorders were ascertained by means of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Personality disorders were assessed with the Structured Clinical Interview for DSM, Revised Third Edition, Personality Disorders (SCID-II).
The prevalence of any mood disorder and any anxiety disorder in women with HG was 15.4% and 36.5%, respectively. In addition, 19 (36.5%) of the patients with HG had at least one personality disorder. According to reports collected from the participants in the study, most of the mood or anxiety disorders occurred before the pregnancy in women with HG. The prevalence of major depression, generalized anxiety disorder, avoidant personality disorder and obsessive-compulsive personality disorder was significantly higher in women with HG compared to the control subjects.
The results of the present study suggest that mood and anxiety disorders, and personality disturbances are frequently observed among women with HG and that there is a potential relationship between these psychiatric disorders and HG during pregnancy.
妊娠剧吐（HG）是孕妇中较为常见的医学问题，其表现为顽固性恶心和呕吐。尽管有一些研究是基于精神症状量表进行的，但 HG 与精神障碍，特别是焦虑和人格障碍之间的关系尚不清楚。本研究旨在探讨 HG 孕妇与非 HG 孕妇在心境、焦虑和人格障碍的发生频率方面是否存在差异。
研究样本由 52 例 HG 患者和 90 例对照孕妇组成。使用《精神障碍诊断与统计手册》第 4 版（DSM-IV）定式临床访谈对心境和焦虑障碍进行确定。人格障碍采用《DSM-III-R 人格障碍定式临床访谈》（SCID-II）进行评估。
HG 孕妇心境障碍和焦虑障碍的总患病率分别为 15.4%和 36.5%。此外，19 例（36.5%）HG 患者至少存在一种人格障碍。根据研究参与者的报告，HG 患者的大部分心境或焦虑障碍发生在怀孕前。与对照组相比，HG 孕妇中重度抑郁症、广泛性焦虑障碍、回避型人格障碍和强迫型人格障碍的患病率明显更高。
本研究结果表明，HG 孕妇中常出现心境和焦虑障碍，以及人格障碍，这些精神障碍与妊娠剧吐之间可能存在一定的关系。
