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中国人群血压变化对主要不良心血管事件的短期结局影响大于长期结局。

Blood Pressure Changes in a Chinese Population Have a Greater Impact on Short-Term Outcomes Rather Than Long-Term Outcomes of Major Adverse Cardiovascular Events.

机构信息

Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Liaoning Provincial Center for Disease Control and Prevention, Shenyang, People's Republic of China.

出版信息

Asia Pac J Public Health. 2021 Jan;33(1):39-45. doi: 10.1177/1010539520955088. Epub 2020 Sep 15.

Abstract

The purpose of our study was to explore the association of blood pressure (BP) changes on short-and long-term outcomes of major adverse cardiovascular events (MACEs) in rural China. This study was designed to learn the effects of BP changes (2004-2008) on short-term (2008-2010, within 2 years of the initial examination) and long-term (2008-2017) outcomes of MACE, including 24 285 and 27 290 participants, respectively. In this study, 423 (short-term) and 1952 (long-term) MACEs were identified. For prehypertension to hypertension, the risk of long-term stroke was increased (hazard ratio [HR] = 1.18 [1.00-1.39]). For hypertension to prehypertension, the short-term MACE risk (0.65 [0.47-0.90]), short-term stroke risk (0.45 [0.26-0.76]), and long-term stroke risk (0.83 [0.70-0.99]) all decreased. Short-term outcomes conferred a stronger impact than long-term outcomes (Fisher test, measured as the difference of β coefficients, all < .05).

摘要

本研究旨在探讨中国农村人群血压(BP)变化与主要不良心血管事件(MACE)短期和长期结局的相关性。该研究旨在探讨 BP 变化(2004-2008 年)对 MACE 短期(2008-2010 年,初始检查后 2 年内)和长期(2008-2017 年)结局的影响,分别纳入了 24285 和 27290 名参与者。在本研究中,分别确定了 423 例(短期)和 1952 例(长期)MACE。对于从正常高值血压到高血压,长期中风风险增加(风险比[HR] = 1.18[1.00-1.39])。对于高血压到正常高值血压,短期 MACE 风险(0.65[0.47-0.90])、短期中风风险(0.45[0.26-0.76])和长期中风风险(0.83[0.70-0.99])均降低。短期结局的影响强于长期结局(Fisher 检验,β系数差异的测量值,均<0.05)。

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