College of Medicine, King Saud Bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia.
Clinical Pharmacy, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Expert Rev Anti Infect Ther. 2021 Mar;19(3):393-398. doi: 10.1080/14787210.2020.1822736. Epub 2020 Sep 20.
Carbapenem-resistant (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units.
This was a retrospective matched case-control study of patients admitted to ICUs. Patients who have positive cultures of CRE and carbapenem-susceptible (CSE) were included in the study. Patients were randomly selected from a pool of CSE subjects in a ratio of 1:1 of CRE to CSE as control patients.
The infection rate with CRE among all patients admitted to ICUs was 7.6% and the incidence of CRE infection was 5.6 per 1,000 person-day. The risk factors independently associated with CRE infection were: Higher Sequential Organ Failure Assessment (SOFA) and Nutrition Risk in Critically ill (NUTRIC) scores, prolonged ICU length of stay (LOS), previous surgery, dialysis and mechanical ventilation during ICU stay, and previous use of aminoglycoside and carbapenems.
In this retrospective study, the incidence of CRE infection was relatively elevated in patients admitted to ICU. Patients with high SOFA and NUTRIC scores, prolonged ICU LOS, previous surgery, dialysis and mechanical ventilation, and prior aminoglycosides and carbapenems use, may have an increased risk of CRE infection.
耐碳青霉烯肠杆菌科（CRE）感染与重症监护病房（ICU）入住、发病率和死亡率有关。我们的研究旨在确定 ICU 中 CRE 的发病率、危险因素和患者结局。
这是一项 ICU 住院患者的回顾性匹配病例对照研究。CRE 阳性培养和碳青霉烯敏感（CSE）的患者纳入研究。从 CSE 患者中随机抽取患者，与 CRE 患者以 1:1 的比例作为对照患者。
所有 ICU 住院患者中 CRE 的感染率为 7.6%，CRE 感染的发病率为每 1000 人日 5.6 例。与 CRE 感染独立相关的危险因素是：更高的序贯器官衰竭评估（SOFA）和危重症营养风险（NUTRIC）评分、ICU 住院时间延长、既往手术、透析和机械通气，以及 ICU 期间使用氨基糖苷类和碳青霉烯类药物。
在这项回顾性研究中，ICU 住院患者的 CRE 感染发生率相对较高。SOFA 和 NUTRIC 评分较高、ICU 住院时间延长、既往手术、透析和机械通气以及先前使用氨基糖苷类和碳青霉烯类药物的患者，可能有更高的 CRE 感染风险。
