Angleton G M, Benjamin S A, Lee A C
Department of Radiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Radiat Res. 1988 Jul;115(1):70-83.
As part of a long-term study of the effects of irradiation during development, prenatal and early neonatal mortality were evaluated for beagles exposed in utero at 8 days postcoitus (dpc), 28 dpc, 55 dpc, or 2 days postpartum. Mean doses used were 0,0.16, or 0.83 Gy. A decrease in whelping rates was observed for female breeders irradiated at 8 dpc. There was a significant decrease in litter sizes from female breeders irradiated at 8 and 28 dpc. Both of these findings are indicative of increased embryonic mortality. There was a significant decrease in the percentage of females born after exposures given at 28 dpc, indicating a differential radiosensitivity by sex. A significant increase in early neonatal mortality up to 14 days of age was observed for beagles exposed 8 or 28 dpc, again with an excess mortality in females.
作为一项关于发育过程中辐射影响的长期研究的一部分，对在交配后8天（dpc）、28 dpc、55 dpc或产后2天子宫内受到照射的比格犬的产前和早期新生儿死亡率进行了评估。使用的平均剂量为0、0.16或0.83 Gy。在8 dpc接受照射的雌性繁殖犬的产仔率有所下降。在8和28 dpc接受照射的雌性繁殖犬的窝仔数显著减少。这两个发现都表明胚胎死亡率增加。在28 dpc接受照射后出生的雌性比例显著下降，表明存在性别差异的放射敏感性。在8或28 dpc接受照射的比格犬中，观察到14日龄前的早期新生儿死亡率显著增加，同样雌性的死亡率过高。
