Benjamin S A, Lee A C, Angleton G M, Saunders W J, Miller G K, Williams J S, Brewster R D, Long R I
J Natl Cancer Inst. 1986 Aug;77(2):563-71.
For a study of the life-time effects of irradiation during development, 1,680 beagles were given single, whole-body exposures to 60Co gamma-radiation at one of three prenatal (preimplantation, embryonic, and fetal) or at one of three postnatal (neonatal, juvenile, and young adult) ages. Mean doses were 0, 0.16, or 0.83 Gy. For comparison with data on childhood cancer after prenatal irradiation, examination was made of tumors occurring in young dogs in this life-span experiment. Up to 4 years of age, 18 dogs had neoplasms diagnosed, 2 of these being in controls. Four dogs that were irradiated in the perinatal (late fetal or neonatal) period died of cancers prior to 2 years of age. This risk was of significant increase compared to the risks for other experimental groups and for the canine population in general. Overall, 71% (5 of 7) of all cancers and 56% (10 of 18) of all benign and malignant neoplasms seen in the first 4 years of life occurred in 29% (480 of 1,680) of the dogs irradiated in the perinatal period. These data suggest an increased risk for neoplasia after perinatal irradiation in dogs.
为研究发育期间辐射的终生影响，1680只比格犬在三个产前阶段（植入前、胚胎期和胎儿期）之一或三个产后阶段（新生儿期、幼年期和青年期）之一接受单次全身60Coγ辐射。平均剂量分别为0、0.16或0.83戈瑞。为了与产前辐射后儿童癌症的数据进行比较，在这个寿命实验中对幼犬发生的肿瘤进行了检查。在4岁之前，有18只犬被诊断患有肿瘤，其中2只在对照组。4只在围产期（胎儿晚期或新生儿期）接受辐射的犬在2岁之前死于癌症。与其他实验组和一般犬类群体的风险相比，这种风险显著增加。总体而言，在生命的前4年中出现的所有癌症中有71%（7只中的5只）以及所有良性和恶性肿瘤中有56%（18只中的10只）发生在29%（1680只中的480只）围产期接受辐射的犬中。这些数据表明犬在围产期辐射后发生肿瘤的风险增加。
