Department of Child and Adolescent Psychiatry, APHP, Groupe Hospitalier Pitié-Salpêtrière, Université Sorbonne, Paris, France.
Department of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, Nice, France.
J Child Adolesc Psychopharmacol. 2021 Feb;31(1):4-32. doi: 10.1089/cap.2020.0014. Epub 2020 Sep 15.
To review the use of aripiprazole in children and adolescents. Medline and Embase databases were systematically searched using the keywords and or over the period from 2000 to 2019. The initial screen yielded 163 publications, from which 99 studies were reviewed. Aripiprazole is one of the most widely prescribed atypical antipsychotics. Like others, its use in children and adolescents is becoming commonplace and occurs in off-label indications. Aripiprazole has proven efficacy for several indications in children and adolescents, including schizophrenia, bipolar disorder, Tourette's syndrome, and behavioral impairments associated with autism and intellectual disability. Adverse effects are more important in children and adolescents than adults, particularly weight gain, drowsiness, extrapyramidal effects, and metabolic effects, even though the latter may appear less important than with other atypical antipsychotics. Severe adverse effects often occur in multiple-prescription settings. At present, postprescription monitoring is very poor. Aripiprazole has proven efficacy for several indications in children and adolescents. However, its use requires clinical and paraclinical monitoring to assess the occurrence of adverse events that may challenge the benefit/risk ratio. In addition, off-label prescriptions should be limited, as they appear to account for a significant proportion of aripiprazole use worldwide.
回顾阿立哌唑在儿童和青少年中的应用。通过使用关键词“和”或“或”，在 2000 年至 2019 年期间，系统地在 Medline 和 Embase 数据库中进行了搜索。初始筛选得到了 163 篇出版物，其中 99 项研究进行了综述。阿立哌唑是最广泛使用的非典型抗精神病药之一。与其他药物一样，它在儿童和青少年中的使用越来越普遍，并且用于标签外的适应症。阿立哌唑已被证明对几种儿童和青少年的适应症有效，包括精神分裂症、双相情感障碍、妥瑞氏症以及与自闭症和智力残疾相关的行为障碍。不良反应在儿童和青少年中比在成年人中更为重要，尤其是体重增加、嗜睡、锥体外系效应和代谢效应，尽管后者可能比其他非典型抗精神病药显得不那么重要。严重不良反应通常发生在多种药物处方的情况下。目前，药物使用后的监测非常差。阿立哌唑已被证明对几种儿童和青少年的适应症有效。然而，其使用需要临床和临床前监测，以评估不良反应的发生，这可能会影响其获益/风险比。此外，应限制标签外处方，因为它们似乎占全球阿立哌唑使用的很大一部分。
