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阿立哌唑致 17 岁男性横纹肌溶解症

Aripiprazole-Associated Rhabdomyolysis in a 17-Year-Old Male.

机构信息

Department of Psychology, Istanbul Esenyurt University, Faculty of Art and Social Sciences, Esenyurt, Istanbul, Turkey.

Department of Child and Adolescent Psychiatry, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Konak, Izmir, Turkey.

出版信息

Arch Iran Med. 2023 Jan 1;26(1):50-53. doi: 10.34172/aim.2023.08.

Abstract

Rhabdomyolysis is a rare serious side effect of antipsychotic medication use. There are cases of rhabdomyolysis due to the use of clozapine, risperidone, olanzapine, and haloperidol in the literature. In this report, we describe a rhabdomyolysis case developed on the 13th day of using 2.5 mg /day aripiprazole in a 17-year-old male patient with a diagnosis of somatic symptom disorder. This case is one of the youngest in the literature to develop rhabdomyolysis after the use of aripiprazole. Moreover, this case is distinguished from the others with its low-dose, short-term and single antipsychotic use. In the child and adolescent age group, routine blood tests should be done before starting medication. Symptoms that appear to be nonspecific and that may be overlooked or may be thought to be caused by an existing psychiatric complaint should be carefully and thoroughly considered during follow-up.

摘要

横纹肌溶解症是抗精神病药物使用的一种罕见严重副作用。文献中有使用氯氮平、利培酮、奥氮平和氟哌啶醇导致横纹肌溶解症的案例。在本报告中,我们描述了 1 例 17 岁男性躯体症状障碍患者,使用阿立哌唑 2.5mg/天治疗第 13 天发生横纹肌溶解症。该病例是文献中使用阿立哌唑后发生横纹肌溶解症最年轻的病例之一。此外,该病例与其他病例的区别在于其使用低剂量、短期和单一抗精神病药物。在儿童和青少年年龄组,开始用药前应进行常规血液检查。在随访期间,应仔细和彻底考虑看似非特异性且可能被忽视或可能被认为是由现有精神科投诉引起的症状。

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本文引用的文献

1
Aripiprazole in Children and Adolescents.阿立哌唑在儿童和青少年中的应用。
J Child Adolesc Psychopharmacol. 2021 Feb;31(1):4-32. doi: 10.1089/cap.2020.0014. Epub 2020 Sep 15.
2
Rhabdomyolysis.横纹肌溶解症。
Dis Mon. 2020 Aug;66(8):101015. doi: 10.1016/j.disamonth.2020.101015. Epub 2020 Jun 10.
4
Antipsychotic use and the risk of rhabdomyolysis.抗精神病药物的使用与横纹肌溶解症的风险。
J Pharm Pract. 2014 Oct;27(5):501-12. doi: 10.1177/0897190013516509. Epub 2014 Jan 15.

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