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阿立哌唑致 17 岁男性横纹肌溶解症

Aripiprazole-Associated Rhabdomyolysis in a 17-Year-Old Male.

机构信息

Department of Psychology, Istanbul Esenyurt University, Faculty of Art and Social Sciences, Esenyurt, Istanbul, Turkey.

Department of Child and Adolescent Psychiatry, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Konak, Izmir, Turkey.

出版信息

Arch Iran Med. 2023 Jan 1;26(1):50-53. doi: 10.34172/aim.2023.08.

DOI:10.34172/aim.2023.08
PMID:37543922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10685809/
Abstract

Rhabdomyolysis is a rare serious side effect of antipsychotic medication use. There are cases of rhabdomyolysis due to the use of clozapine, risperidone, olanzapine, and haloperidol in the literature. In this report, we describe a rhabdomyolysis case developed on the 13th day of using 2.5 mg /day aripiprazole in a 17-year-old male patient with a diagnosis of somatic symptom disorder. This case is one of the youngest in the literature to develop rhabdomyolysis after the use of aripiprazole. Moreover, this case is distinguished from the others with its low-dose, short-term and single antipsychotic use. In the child and adolescent age group, routine blood tests should be done before starting medication. Symptoms that appear to be nonspecific and that may be overlooked or may be thought to be caused by an existing psychiatric complaint should be carefully and thoroughly considered during follow-up.

摘要

横纹肌溶解症是抗精神病药物使用的一种罕见严重副作用。文献中有使用氯氮平、利培酮、奥氮平和氟哌啶醇导致横纹肌溶解症的案例。在本报告中,我们描述了 1 例 17 岁男性躯体症状障碍患者,使用阿立哌唑 2.5mg/天治疗第 13 天发生横纹肌溶解症。该病例是文献中使用阿立哌唑后发生横纹肌溶解症最年轻的病例之一。此外,该病例与其他病例的区别在于其使用低剂量、短期和单一抗精神病药物。在儿童和青少年年龄组,开始用药前应进行常规血液检查。在随访期间,应仔细和彻底考虑看似非特异性且可能被忽视或可能被认为是由现有精神科投诉引起的症状。

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Aripiprazole-Associated Rhabdomyolysis in a 17-Year-Old Male.阿立哌唑致 17 岁男性横纹肌溶解症
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Cureus. 2024 Aug 29;16(8):e68127. doi: 10.7759/cureus.68127. eCollection 2024 Aug.

本文引用的文献

1
Aripiprazole in Children and Adolescents.阿立哌唑在儿童和青少年中的应用。
J Child Adolesc Psychopharmacol. 2021 Feb;31(1):4-32. doi: 10.1089/cap.2020.0014. Epub 2020 Sep 15.
2
Rhabdomyolysis.横纹肌溶解症。
Dis Mon. 2020 Aug;66(8):101015. doi: 10.1016/j.disamonth.2020.101015. Epub 2020 Jun 10.
3
Paliperidone-induced rhabdomyolysis: a case report.帕利哌酮诱发的横纹肌溶解症:一例报告
Actas Esp Psiquiatr. 2015 Mar-Apr;43(2):66-8. Epub 2015 Mar 1.
4
Antipsychotic use and the risk of rhabdomyolysis.抗精神病药物的使用与横纹肌溶解症的风险。
J Pharm Pract. 2014 Oct;27(5):501-12. doi: 10.1177/0897190013516509. Epub 2014 Jan 15.
5
Weight gain and other metabolic adverse effects associated with atypical antipsychotic treatment of children and adolescents: a systematic review and meta-analysis.儿童和青少年使用非典型抗精神病药物治疗导致的体重增加和其他代谢不良反应:系统评价和荟萃分析。
Paediatr Drugs. 2013 Apr;15(2):139-50. doi: 10.1007/s40272-013-0016-6.
6
Rhabdomyolysis reported for children and adolescents treated with antipsychotic medicines: a case series analysis.抗精神病药物治疗儿童和青少年横纹肌溶解症报告:病例系列分析
J Child Adolesc Psychopharmacol. 2012 Dec;22(6):440-51. doi: 10.1089/cap.2011.0134.
7
Rhabdomyolysis in a patient on aripiprazole with traumatic hip prosthesis luxation.使用阿立哌唑的患者发生横纹肌溶解症并伴有创伤性髋关节假体脱位。
J Neuropsychiatry Clin Neurosci. 2012 Fall;24(4):E40-1. doi: 10.1176/appi.neuropsych.11110328.
8
Aripiprazole-associated rhabdomyolysis in a patient with schizophrenia.一名精神分裂症患者出现与阿立哌唑相关的横纹肌溶解症。
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):E51. doi: 10.1176/jnp.23.3.jnpe51.
9
The modern spectrum of rhabdomyolysis: drug toxicity revealed by creatine kinase screening.横纹肌溶解症的现代谱系:通过肌酸激酶筛查揭示的药物毒性
Curr Drug Saf. 2009 Sep;4(3):181-7. doi: 10.2174/157488609789007010. Epub 2009 Sep 1.
10
Acute pediatric rhabdomyolysis: causes and rates of renal failure.急性小儿横纹肌溶解症:肾衰竭的病因及发生率
Pediatrics. 2006 Nov;118(5):2119-25. doi: 10.1542/peds.2006-1352.