Division of Pediatric Hematology-Oncology, Saint George Hospital University Medical Center , Beirut, Lebanon.
Division of Hematology and Oncology, Department of Internal Medicine, Makassed General Hospital , Beirut, Lebanon.
Expert Rev Hematol. 2020 Oct;13(10):1081-1092. doi: 10.1080/17474086.2020.1819785. Epub 2020 Sep 15.
Many patients with inherited or acquired benign hematological disorders are at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific advice regarding isolation and changes to their usual treatment schedules. Their disease can also be associated with significant burden, and they necessitate life-long and regular access to therapy, and regular follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting many challenges for these patients, their families, and health-care professionals.
This review provides an overview of the reported COVID-19 cases in the literature in patients with certain benign hematological disorders including thalassemia, sickle cell disease, hemophilia, immune thrombocytopenia, venous thromboembolism, and aplastic anemia. The review also outlines some recommendations on how to manage these patients if they are infected with SARS-CoV-2. To review the literature on benign hematological disorders and COVID-19, a bibliographic search was performed using PubMed for articles published between January 2020 and June 2020.
International efforts must be made to continue reporting and better understanding the effects of SARS-CoV-2 infection in these patients and accordingly develop a set of recommendations to optimize the treatment of future infected patients.
许多患有遗传性或获得性良性血液疾病的患者因 COVID-19 而面临严重并发症的风险增加。因此，这些患者需要关于隔离和改变其常规治疗方案的具体建议。他们的疾病也可能带来很大的负担，需要终身和定期接受治疗，并定期进行随访咨询和医院就诊。因此，当前的 COVID-19 大流行给这些患者、他们的家人和医疗保健专业人员带来了许多挑战。
本综述概述了文献中报告的某些良性血液疾病患者（包括地中海贫血、镰状细胞病、血友病、免疫性血小板减少症、静脉血栓栓塞和再生障碍性贫血）感染 SARS-CoV-2 的 COVID-19 病例。还概述了一些关于如何管理这些患者的建议。为了回顾良性血液疾病和 COVID-19 的文献，使用 PubMed 对 2020 年 1 月至 6 月期间发表的文章进行了文献检索。
必须做出国际努力，继续报告并更好地了解 SARS-CoV-2 感染对这些患者的影响，并相应地制定一系列建议，以优化未来感染患者的治疗。
