Carvajal A, Frederiksen W
Department of Diagnostic Bacteriology, Statens Seruminstitut, Copenhagen, Denmark.
Rev Infect Dis. 1988 May-Jun;10(3):616-23. doi: 10.1093/clinids/10.3.616.
Three fatal cases of listerial endocarditis were studied. The first case occurred in an apparently healthy 58-year-old man, who presented with symptoms of pneumonitis. The second case developed in a 75-year-old woman with adenocarcinoma of the lung and aortic stenosis. In the third patient, an 83-year-old woman, aortic valve vegetations with perforations were found at necropsy. A colonic adenocarcinoma was found in the first and third cases. Ampicillin, alone or with an aminoglycoside, was the antibiotic used. Urgent valve replacement was performed in the first case. Listeria monocytogenes was isolated from blood cultures in all three cases. A review of 41 other patients with listerial endocarditis showed a nonspecific clinical picture, but septic complications occurred in one-half of the cases. Thirty-nine patients had at least one predisposing factor, which was underlying heart disease in 25 cases. The mortality rate was 48%.
对三例李斯特菌性心内膜炎致死病例进行了研究。首例病例发生在一名看似健康的58岁男性身上，他表现出肺炎症状。第二例发生在一名75岁患有肺腺癌和主动脉狭窄的女性身上。第三例患者是一名83岁女性，尸检时发现主动脉瓣有赘生物并伴有穿孔。在第一例和第三例病例中发现了结肠腺癌。使用的抗生素是氨苄西林，单独使用或与氨基糖苷类联合使用。第一例病例进行了紧急瓣膜置换。在所有三例病例的血培养中均分离出单核细胞增生李斯特菌。对其他41例李斯特菌性心内膜炎患者的回顾显示，临床表现不具有特异性，但半数病例出现了败血症并发症。39例患者至少有一个易感因素，其中25例的易感因素是潜在的心脏病。死亡率为48%。
