血液恶性肿瘤免疫多样性的多层分子壁画。

A Multi-layer Molecular Fresco of the Immune Diversity across Hematologic Malignancies.

机构信息

Cancer Research Department, Sidra Medicine, Doha, Qatar; Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy.

出版信息

Cancer Cell. 2020 Sep 14;38(3):313-316. doi: 10.1016/j.ccell.2020.08.013.

DOI:10.1016/j.ccell.2020.08.013

PMID:32931741

Abstract

Immune checkpoint blockade has limited activity in the large majority of hematologic malignancies. In this issue of Cancer Cell, Dufva et al. provide an immunologic portrait of these heterogenous diseases and identify key relationships between oncogenic states and immune response that can spur the development of more efficient immunotherapeutic approaches.

摘要

免疫检查点阻断在绝大多数血液恶性肿瘤中的活性有限。在本期《癌细胞》中，Dufva 等人提供了这些异质性疾病的免疫学特征，并确定了致癌状态与免疫反应之间的关键关系，这些关系可以促进更有效的免疫治疗方法的发展。