School of Nanoscience and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Department of Physics, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Nanotechnology. 2021 Jan 8;32(2):025504. doi: 10.1088/1361-6528/abb8a8.
Self-assembled hierarchical nanostructures are slowly superseding their conventional counterparts for use in biosensors. These morphologies show high surface area with tunable porosity and packing density. Modulating the interfacial interactions and subsequent particle assembly occurring at the water-and-oil interface in inverse miniemulsions, are amongst the best strategies to stabilize various type of hollow nanostructures. The paper presents a successful protocol to obtain CeO hollow structures based biosensors that are useful for glucose to protein sensing. The fabricated glucose sensor is able to deliver high sensitivity (0.495 μA cm nM), low detection limit (6.46 nM) and wide linear range (0 nM to 600 nM). CeO based bioelectrode can also be considered as a suitable candidate for protein sensors. It can detect protein concentrations varying from 0 to 30 µM, which is similar or higher than most reports in the literature. The limit of detection (LOD) for protein was ∼0.04 µM. Therefore, the hollow CeO electrodes, with excellent reproducibility, stability and repeatability, open a new area of application for cage-frame type particles.
自组装的分级纳米结构正在慢慢取代传统的同类结构，用于生物传感器。这些形态具有高表面积、可调孔隙率和堆积密度。在反微乳液中调节水-油界面的界面相互作用和随后的颗粒组装，是稳定各种类型的中空纳米结构的最佳策略之一。本文提出了一种成功的方案，用于获得基于 CeO 的空心结构生物传感器，该传感器可用于葡萄糖到蛋白质的传感。所制备的葡萄糖传感器具有高灵敏度（0.495 μA cm nM）、低检测限（6.46 nM）和宽线性范围（0 nM 至 600 nM）。CeO 基生物电极也可以被认为是蛋白质传感器的合适候选者。它可以检测从 0 到 30 µM 的蛋白质浓度，这与文献中的大多数报道相似或更高。蛋白质的检测限（LOD）约为 0.04 µM。因此，具有优异的重现性、稳定性和可重复性的空心 CeO 电极，为笼式结构颗粒开辟了一个新的应用领域。
