Cornea and Contact Lens Department, De Lens Family Eye and Vision Care Center, Abuja, Nigeria.
Optom Vis Sci. 2020 Sep;97(9):720-725. doi: 10.1097/OPX.0000000000001568.
Scleral lens wear can alter aqueous fluid and anterior chamber angle dynamics, leading to changes in intraocular pressure (IOP). However, there is limited information supporting this relationship between scleral lens wear, anterior chamber angle (ACA), and IOP changes in an black African population.
The purpose of this study was to compare scleral IOP and ACA before, during, and after 4 hours of scleral lens wear in healthy neophyte scleral lens wearers from an black African population.
This was a prospective study involving 20 eyes of 20 subjects with a mean ± standard deviation age of 28.7 ± 4.3 years. The study was divided into a screening and experimental phase. Scleral lenses from a diagnostic trial set were fit on a randomly selected eye. Scleral IOP was measured using a Schiotz tonometer (Winters, Jungingen, Germany) (weight, 7.5 g) on the superior-temporal sclera, and ACA was assessed using anterior segment optical coherence tomography on the temporal angle before scleral lens wear; at 10 minutes, 2 hours, and 4 hours during wear; and 10 minutes after scleral lens removal.
The mean ± standard deviation base curve of the scleral lens fit in the study eye was 43.4 ± 1.3 D with average tear reservoir thickness of 288.1 ± 122.0 μm at 4 hours. The mean scleral IOP before lens wear was 17.2 ± 3.5 mmHg, decreased to 16.4 ± 4.5 mmHg at 4 hours of scleral lens wear, and was 16.6 ± 3.5 mmHg 10 minutes after lens removal. The temporal ACA before scleral lens application was 43.0 ± 6.6° and varied during the 4 hours of scleral lens wear, ultimately increasing to 45.0 ± 5.4° at 10 minutes after scleral lens removal. The change in IOP and ACA was not statistically significant (F = 0.501, P = .74; and F = 2.399, P = .09, respectively).
Results suggest that 4 hours of nonfenestrated scleral lens wear did not have a significant impact on IOP or ACA in most of our study population.
巩膜镜佩戴可改变房水和前房角动力学，导致眼压（IOP）变化。然而，在黑非洲人群中，关于巩膜镜佩戴、前房角（ACA）和IOP 变化之间的这种关系，仅有有限的信息支持。
本研究旨在比较黑非洲新佩戴巩膜镜者在佩戴巩膜镜 4 小时前、中、后的巩膜IOP 和 ACA。
这是一项前瞻性研究，共纳入 20 名受试者的 20 只眼，平均年龄为 28.7 ± 4.3 岁。该研究分为筛选和实验两个阶段。将诊断试戴片的巩膜镜随机应用于一只眼。使用 Schiotz 眼压计（Winters，德国 Jungingen）（重量 7.5 g）测量上颞部巩膜的巩膜 IOP，使用前节光学相干断层扫描（OCT）在颞角测量 ACA，在佩戴巩膜镜前；佩戴 10 分钟、2 小时和 4 小时时；以及巩膜镜取出后 10 分钟。
研究眼中巩膜镜的平均基弧 ± 标准差为 43.4 ± 1.3 D，平均泪液储库厚度为 288.1 ± 122.0 μm，在 4 小时时。佩戴巩膜镜前的平均巩膜 IOP 为 17.2 ± 3.5 mmHg，佩戴 4 小时后降至 16.4 ± 4.5 mmHg，佩戴后 10 分钟时为 16.6 ± 3.5 mmHg。巩膜镜应用前颞部 ACA 为 43.0 ± 6.6°，在佩戴 4 小时期间发生变化，最终在巩膜镜取出后 10 分钟时增加至 45.0 ± 5.4°。IOP 和 ACA 的变化无统计学意义（F = 0.501，P =.74；和 F = 2.399，P =.09）。
结果表明，在大多数研究人群中，4 小时的非开窗巩膜镜佩戴对 IOP 或 ACA 没有显著影响。
