Johnson L L
Trudeau Institute, Inc., Saranac Lake, New York 12983.
Transplantation. 1988 Jul;46(1):132-7. doi: 10.1097/00007890-198807000-00024.
Intravenous infusions of spleen cells bearing single minor H antigens have been shown to induce an antigen-specific prolongation of survival of subsequently applied skin grafts bearing the infused antigen. In this report it is shown that i.v. infusion of spleen cells bearing only H-Y as an alloantigen fails to prolong the survival of subsequently applied skin grafts bearing H-Y and additional H antigens. In contrast, others have shown that the i.v. infusion of alloantigen-bearing cells can inhibit DTH reactions, CTL generation, or organ allograft rejection directed against additional alloantigens, provided they are present in the challenge inoculum or graft together with the i.v.-infused antigens. Several possible reasons for the discrepancy between the results with skin grafts, and the results of others using different assays of responsiveness to H antigens are examined.
已证明静脉输注携带单一次要组织相容性抗原的脾细胞可诱导随后移植的携带所输注抗原的皮肤移植物存活期出现抗原特异性延长。在本报告中表明，静脉输注仅携带H-Y作为同种异体抗原的脾细胞不能延长随后移植的携带H-Y和其他H抗原的皮肤移植物的存活期。相比之下，其他人已表明，静脉输注携带同种异体抗原的细胞可抑制针对其他同种异体抗原的迟发型超敏反应、细胞毒性T淋巴细胞生成或器官同种异体移植排斥反应，前提是它们与静脉输注的抗原一起存在于激发接种物或移植物中。本文研究了皮肤移植结果与其他人使用不同H抗原反应性检测方法所得结果之间差异的几种可能原因。
