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2
Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD).神经疾病的免疫基因网络：多发性硬化症（MS）、阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）。
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Advances in oligonucleotide drug delivery.寡核苷酸药物递送的进展。
Nat Rev Drug Discov. 2020 Oct;19(10):673-694. doi: 10.1038/s41573-020-0075-7. Epub 2020 Aug 11.
2
The belated US FDA approval of the adenosine A receptor antagonist istradefylline for treatment of Parkinson's disease.美国食品和药物管理局（FDA）姗姗来迟，批准腺苷 A 受体拮抗剂伊曲茶碱用于治疗帕金森病。
Purinergic Signal. 2020 Jun;16(2):167-174. doi: 10.1007/s11302-020-09694-2. Epub 2020 Mar 31.
3
Current and Future Treatments in Alzheimer Disease: An Update.阿尔茨海默病的当前及未来治疗方法：最新进展
J Cent Nerv Syst Dis. 2020 Feb 29;12:1179573520907397. doi: 10.1177/1179573520907397. eCollection 2020.
4
Diagnosis and Treatment of Parkinson Disease: A Review.帕金森病的诊断与治疗：综述。
JAMA. 2020 Feb 11;323(6):548-560. doi: 10.1001/jama.2019.22360.
5
A resurrection of aducanumab for Alzheimer's disease.阿杜卡单抗用于治疗阿尔茨海默病的再度兴起。
Lancet Neurol. 2020 Feb;19(2):111-112. doi: 10.1016/S1474-4422(19)30480-6. Epub 2019 Dec 4.
6
Therapeutic Advances for Huntington's Disease.亨廷顿舞蹈症的治疗进展
Brain Sci. 2020 Jan 12;10(1):43. doi: 10.3390/brainsci10010043.
7
Insights into Computational Drug Repurposing for Neurodegenerative Disease.计算药物重用到神经退行性疾病的研究进展。
Trends Pharmacol Sci. 2019 Aug;40(8):565-576. doi: 10.1016/j.tips.2019.06.003. Epub 2019 Jul 17.
8
Targeting Huntingtin Expression in Patients with Huntington's Disease.靶向亨廷顿病患者的亨廷顿蛋白表达。
N Engl J Med. 2019 Jun 13;380(24):2307-2316. doi: 10.1056/NEJMoa1900907. Epub 2019 May 6.
9
Modern approaches to investigating non-neuronal aspects of Alzheimer's disease.现代方法研究阿尔茨海默病的非神经元方面。
FASEB J. 2019 Feb;33(2):1528-1535. doi: 10.1096/fj.201802592.
10
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches.神经退行性疾病：再生机制与新型治疗方法
Brain Sci. 2018 Sep 15;8(9):177. doi: 10.3390/brainsci8090177.

神经退行性疾病治疗方法开发的最新进展与未来展望

Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases.

作者信息

Bowerman Melissa

机构信息

School of Medicine, Keele University, Staffordshire ST5 5BG, UK.

Wolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Oswestry SY10 7AG, UK.

出版信息

Brain Sci. 2020 Sep 11;10(9):633. doi: 10.3390/brainsci10090633.

DOI:10.3390/brainsci10090633
PMID:32932920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7565049/
Abstract

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), severely impact the function of neuronal cells in the brain and have devastating consequences on the quality of life of patients and their families [...].

摘要

神经退行性疾病，如阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD），严重影响大脑中神经元细胞的功能，并对患者及其家人的生活质量产生毁灭性影响[……]。