West Pomeranian Center of Treating Severe Burns and Plastic Surgery in Gryfice, 72-300 Gryfice, Poland.
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460, Szczecin, Poland.
Nutrients. 2020 Sep 11;12(9):2780. doi: 10.3390/nu12092780.
Burned patients have an increased need for vitamin D supply related to the maintenance of calcium-phosphate homeostasis and the regulation of cell proliferation/differentiation. This study aimed to analyze the concentration of 25-hydroxycholecalciferol and its relationship with severe condition after burn injury.
126 patients were enrolled in the study. Patients were qualified due to thermal burns-over 10% of total body surface area. On the day of admission, the following parameters were assessed: 25-hydroxycholecalciferol concentration, total protein concentration, albumin concentration, aspartate transaminase activity, alanine transaminase activity, albumin concentration, creatinine concentration, c-reactive protein concentration, procalcitonin concentration, and interleukin-6 concentration.
Almost all patients (92%) in the study group had an improper level of vitamin D (<30 ng/mL), with the average of 11.6 ± 10.7 ng/mL; 17.5% of patients had levels of vitamin D below the limit of determination-under 3 ng/mL. The study showed that there are several factors which correlated with vitamin D concentration during the acute phase of burn injury, including: total protein ( = 0.42, < 0.01), albumin, ( = 0.62, < 0.01), percentage of body burns ( = 0.36, < 0.05), aspartate aminotransferase ( = 0.21, < 0.05), and c-reactive protein ( = 0.22, < 0.05). We did not find any significant correlation between vitamin D concentration and body mass index.
The burn injury has an enormous impact on the metabolism and the risk factors of the deficiency for the general population (BMI) have an effect on burned patients. Our study showed that concentration of 25-hydroxycholecalciferol is strongly correlated with serum albumin level, even more than total burn surface area and burn degrees as expected. We suspect that increased supplementation of vitamin D should be based on albumin level and last until albumin levels are balanced.
烧伤患者对维生素 D 供应的需求增加，这与钙磷稳态的维持和细胞增殖/分化的调节有关。本研究旨在分析 25-羟胆钙化醇的浓度及其与烧伤后严重程度的关系。
纳入了 126 名患者进行研究。患者因热烧伤导致全身表面积超过 10%而符合入组条件。在入院当天，评估了以下参数：25-羟胆钙化醇浓度、总蛋白浓度、白蛋白浓度、天门冬氨酸转氨酶活性、丙氨酸转氨酶活性、白蛋白浓度、肌酐浓度、C 反应蛋白浓度、降钙素原浓度和白细胞介素-6 浓度。
研究组几乎所有患者（92%）的维生素 D 水平均不正常（<30ng/mL），平均为 11.6±10.7ng/mL；17.5%的患者维生素 D 水平低于检测下限（<3ng/mL）。研究表明，在烧伤急性期，有几个因素与维生素 D 浓度相关，包括：总蛋白（=0.42，<0.01）、白蛋白（=0.62，<0.01）、烧伤面积百分比（=0.36，<0.05）、天门冬氨酸转氨酶（=0.21，<0.05）和 C 反应蛋白（=0.22，<0.05）。我们没有发现维生素 D 浓度与体重指数之间存在任何显著相关性。
烧伤对维生素 D 代谢有巨大影响，而一般人群（BMI）的危险因素对烧伤患者有影响。我们的研究表明，25-羟胆钙化醇的浓度与血清白蛋白水平强烈相关，甚至比总烧伤面积和烧伤程度更相关。我们怀疑，应根据白蛋白水平增加维生素 D 的补充，并持续到白蛋白水平平衡。
